摘要
目的探讨细胞毒性T淋巴细胞相关抗原4(Cytotoxic T lymphocyteassociated Antigen4,CTLA-4)基因外显子1的A/G多态性与汉族人群弥漫性毒性甲状腺肿(Graves disease,GD)的关系。方法采用多聚酶链反应-限制性片断长度多态性分析(PCR-RFLP)法,检测90名GD患者和90名健康人外周血CTLA-4基因外显子1的基因型并行分析。结果 GD患者的CTLA-4外显子1的A/G49位点GG基因型频率及G等位基因频率较正常对照组显著增高(P<0.001)。结论 CTLA-4基因可能是汉族人群中GD的易感候选基因。
Objective To investigate the association between of cytotoxic Tlymphocyte -associated antigen - 4 （ CTLA - 4） gene polymorphism with Graves disease （GD） in Han population. Methods The polymorphism of cytotoxic T lymphocyte - associated antigen - 4 （ CTLA - 4 ） was investigated by PCR - RFLP in 90 healthy volunteers and 90 patients with GD. Results The frequency of G49 allele of CTLA -4 exon 1 in GD patients was significantly higher than that in normal controls（P 〈0.01 ）. Conclusion CTLA -4 gene seems to be a new susceptible candidate gene of GD in Han population.
出处
《青海医学院学报》
CAS
2010年第4期225-227,245,共4页
Journal of Qinghai Medical College
关键词
CTLA-4基因
Graves病基因多态性
Cytotoxic Tlymphocyte associated antigen- 4 gene Graves disease Gene polymorphism
