摘要
目的观察高聚生联合顺铂治疗恶性胸腔积液的疗效及毒副反应。方法将80例恶性胸腔积液随机分为两组,治疗组40例给予高聚生联合顺铂治疗,对照组40例仅给予顺铂治疗。比较分析两组的疗效和毒副反应。结果治疗组总有效率为80.0%,对照组为52.5%,差异有统计学意义(P<0.01)。治疗组Karnofsky评分好转率90.0%,优于对照组的37.5%,差异有统计学意义(P<0.01)。两组主要毒副反应均为骨髓抑制和消化道反应。结论高聚生联合顺铂胸腔内注射能够有效控制恶性胸腔积液,提高患者生存质量,减少毒副反应。
Objective To observe the therapeutic effect and toxicities of highly agglutinative staphylococcin combined with cisplatin in the treatment of patients with malignant pleural effusion.Methods Eighty patients with malignant pleural effusion were treated.The treatment group： 40 patients were assigned to receive highly agglutinative staphylococcin combined with cisplatin;the control group： 40 patients were assigned to receive cisplatin alone.Results The total effective rate was 80.0% in the treatment group,and 52.5% in the control group（P0.01）.The improvement rate of karnofsky score was 90.0% in the treatment group, and 37.5% in the control group（P0.01）.The main toxicities were marrow depression and gastrointestinal reaction in the two groups.Conclusion Highly agglutinative staphylococcin plus cisplatin can control malignant pleural effusion,improve survival quality,reduce toxicities.
出处
《肿瘤基础与临床》
2010年第5期413-414,共2页
journal of basic and clinical oncology
关键词
高聚生
顺铂
恶性胸腔积液
highly agglutinative staphylococcin cisplatin malignant pleural effusion
