摘要
目的探讨白芍总苷对骨关节炎(OA)患者血清总抗氧化能力(T-AOC)和一氧化氮(NO)水平的影响。方法 80例OA患者随机分成两组,分别给予白芍总苷+对乙酰氨基酚治疗组(A组)、对乙酰氨基酚治疗组(B组)。测量患者在用药前、用药4周后的血清T-AOC、NO水平。结果用药4周后,两组T-AOC均升高,而NO的水平均有所下降,白芍总苷治疗组T-AOC的升高和NO的下降较明显(P<0.05),有统计学意义。结论白芍总苷能有效辅助改善OA患者的病情,降低血清中T-AOC和NO的水平。
Objective To explore the effect of total glucosides of paeonia（TGP） on serum total anti-oxidation capacity（T-AOC） and nitric oxide（NO） in patients with knee osteoarthritis（OA）.Methods 80 patients with osteoarthritis were randomly divided into 2 groups.Group A was treated with TGP combined acetaminophen,but group B with acetaminophen.4 weeks later,the serum T-AOC and NO were detected.Results T-AOC and NO levels of TGP-treated patients were obviously lower than that of patients with acetaminophen.Conclusion TGP can decrease the serum T-AOC and NO levels and improve symptoms of OA patients.
出处
《西部医学》
2011年第2期298-299,共2页
Medical Journal of West China
关键词
骨关节炎
白芍总苷
总抗氧化能力
一氧化氮
Osteoarthritis
Total glucosides of paeonia
Total anti-oxidation capacity
Nitric oxide
