摘要
目的:探讨Bcl-2、P53和TPO在甲状腺肿瘤中表达的意义。方法:应用免疫组化LSAB法,以单克隆抗体鼠抗人Bcl-2、P53和TPO标记检测77例甲状腺癌、58例甲状腺腺瘤、40例癌旁甲状腺组织和28例正常甲状腺组织,观察不同甲状腺组织中Bcl-2、P53和TPO的表达,并比较其阳性率。结果:Bcl-2、P53阳性反应见于甲状腺癌、甲状腺腺瘤及癌旁甲状腺组织。在甲状腺癌组织中Bcl-2、P53阳性率高于甲状腺腺瘤组织、癌旁甲状腺组织和正常甲状腺组织。Bcl-2、P53及TPO表达与甲状腺组织类型及肿瘤病理分型密切相关,显示甲状腺癌中Bc1-2与P53表达呈正相关关系。结论:Bcl-2及P53在甲状腺肿瘤发生中起重要作用,癌组织Bcl-2及P53表达可作为甲状腺癌预后的指标。
Objective： To study the significance of the examination at the same time of Bcl-2、P53 and TPO in thyroid tumor.Methods： The Expression of Bcl-2,P53 and TPO was analyzed by immunohistochemical LSAB method in the tissues from 77 thyroid carcinomas,58 thyroid adenomas,40 thyroid tissues adjacent to cancer and 28 normal thyroid tissues.The positive expression rates in the different thyroid tissues were compared.Results： Bcl-2 and P53 were expressed in thyroid carcinoma,thyroid adenoma,the thyroid tissues adjacent to cancer and non in normal thyroid tissues.The positive expression rate of Bcl-2、P53 in the thyroid carcinoma was significantly higher than that of in thyroid adenoma,thyroid tissues adjacent to cancer and normal thyroid tissues.The results were retrospectively analysed relative to the out-come of patients on follow up.It was shown that Bcl-2,TPO and P53 immunoreaction were closely associated with histological types,pathological typing.It was found that positive Bcl-2 and P53 was in remarkable positively correlated with high recurrent rates of patients.Conclusion： The results suggest that over-expression of Bcl-2 and P53 play an important role in occurrence of thyroid carcinoma and would serve as objective indicator of poor prognosis of thyroid carcinoma.
出处
《中国医药导报》
CAS
2011年第4期19-21,共3页
China Medical Herald
