期刊文献+

中药复方及单味五指毛桃根中补骨脂素大鼠体内药动学研究 被引量:6

The pharmacokinetics of psoralen in compound recipe and hispid fig root in rats
下载PDF
导出
摘要 目的:建立反相高效液相色谱法,分别比较中药复方与单味五指毛桃根提取物中补骨脂素大鼠体内的药动学差别,探讨中药复方对药效成分体内过程的影响。方法:实验大鼠分别灌胃中药复方、五指毛桃根提取物后,测定不同时间点大鼠血浆中补骨脂素浓度,采用药动学程序3P97对数据进行统计学处理,进行药动学模型拟合并计算相关药代动力学参数。结果:复方及五指毛桃根中补骨脂素在大鼠体内均呈一室模型,复方中补骨脂素的吸收滞后时间(Lag time)长于单味药材,其吸收速率常数(Ka)小,吸收半衰期t1/2(ka)长,吸收速度较慢,使得复方两次达峰时间较晚;两者消除速率常数(Ke)、消除半衰期t1/2(ke)比较表明复方排泄较慢,在体内的作用时间稍长;曲线下面积复方大于五指毛桃根,吸收多于后者,生物利用度相对高,两者在Lag time、Tmax(1)及Tmax(2)上存在显著性差异。结论:中药复方与单味药材体内药动学之间存在差异,其产生的原因可能与复方间的相互配伍,复方成型工艺或其中添加辅料有关。 Objective: To compare the pharmacokinetics of psoralen in compound recipe and the extractive of hispid fig root,through Reversed Phase High Performance Liquid Chromatography(RP-HPLC) in rats respectively.To provide a new way to investigate the effect of combination in physiological disposition.Methods: The rats were intragastric administered with compound recipe and hispid fig root.The blood concentration of different time point were tested by the proposed established RP-HPLC and sample processing.The blood concentration data analyzed by the pharmacokinetics program 3P97 were used to determine the parameters of pharmacokinetics and the compart-mental model.Results: Psoralen in compound recipe and the extractive of hispid fig root showed one compartment model in rats.There were significant difference between compound recipe and hispid fig root in Lag time,Tmax(1) and Tmax(2).Compound recipe had slower absorption rate,higher AUC and bioavailability than hispid fig root.Conclusion: There is significant difference between compound recipe and hispid fig root on pharmacokinetics in vivo.The probably reason of them are intercompatibility,modeling technique and adjuvant of compound recipe.
作者 段菊屏
出处 《中国医药导报》 CAS 2011年第4期29-31,共3页 China Medical Herald
关键词 药代动力学 五指毛桃根 补骨脂素 HPLC Pharmacokinetics Hispid fig root Psoralen HPLC
  • 相关文献

参考文献11

二级参考文献69

共引文献166

同被引文献148

引证文献6

二级引证文献45

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部