摘要
目的:优化甘草黄酮的β-环糊精包合工艺。方法:采用正交试验对甘草黄酮-β-环糊精包合的主要参数进行考察,以综合评分为指标,筛选最佳工艺,并采用紫外分光光度法和薄层色谱法对包合物进行物相鉴别。结果:甘草黄酮-β-环糊精包合物的最佳工艺为:甘草黄酮与β-环糊精的投料比为1:10,加水量为β-环糊精的10倍,包合温度40℃,搅拌时间1h。结论:饱和水溶液法制备甘草黄酮-β-环糊精,方法可行,操作简单。
Objective：To optimize the technology of licorice licoflavone β-cyclodextrin package.Method： Main parameters of licorice flavanone-β-cyclodextrin inclusion were investigated by orthogonal experiment with inclu-sion compound and receive rate as the target to screen out the best technology;the inclusion compound was identified by ultraviolet spectrophotometric method and the thin layer chromatography.Result： The best technique of licofla-vone-β-cyclodextrin inclusion compound was as follows： the batch feeding ratio of licoflavone to β-cyclodextrin was 1∶ 10;the water quantity to be added was 10 times of β-cyclodextrin batch feeding＇s;the package temperature was at 40 ℃ and mixed for 1 hour by stirring.Conclusion：The preparation of licoflavone-β-cyclodextrin by saturated aque-ous solution is simple to operate.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第4期30-32,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
新疆维吾尔自治区科技平台建设项目(PT07-08)
新疆维吾尔自治区重点实验室科研开放课题基金(XJDX0910-2009-05)
关键词
甘草黄酮
Β-环糊精
包合工艺
licoflavone
β-cyclodextrin
inclusion technology
