摘要
血管钙化与心血管疾病发生率和死亡率密切相关,在慢性肾脏病(CKD)患者中极为常见,相关机制十分复杂。CKD血管钙化常表现为血管平滑肌细胞向软骨或成骨样细胞转分化,其中高磷血症的作用极为突出,还有其他多种因素可能诱导血管平滑肌细胞转分化。此外,CKD患者循环或局部血管钙化抑制因子的减少也可能与其血管钙化有关。目前临床针对CKD血管钙化尚无公认有效的治疗方案,但积极预防有助于延缓疾病进展。
Vascular calcification is common in chronic kidney disease （CKD）and associated with increased morbidity and mortality of cardiovascular disease. Its mechanism is multi-factorial and incompletely understood. Vascular calcification in CKD is usually characterized as the transdifferentiation of vascular smooth muscle cells to chondrocyte or osteoblast-like cells, especially in hyperphosphatemia. There are other inducers stimulating transdifferentiation of vascular smooth muscle cells as well. Besides, low levels of circulating and locally produces inhibitors in CKD patients are involved in too. Today the effective therapy for vascular calcification is still unavailable while the active prevention should be taken to slow down the progression.
出处
《世界临床药物》
CAS
2011年第2期116-120,共5页
World Clinical Drug
基金
福建省科技计划重点项目(2009Y0040)
关键词
慢性肾脏病
血管钙化
高磷血症
chronic kidney disease
vascular calcification
hyperphosphatemia
