摘要
目的通过测定冠心病患者介入治疗前后血清中凋亡诱导因子(AIF)、细胞色素C(Cyt-C)、凋亡蛋白酶活化因子(Apaf-1)水平的变化,探讨冠状动脉介入治疗(PCI)对冠心病患者血清中AIF、Cyt-C及Apaf-1水平的影响。方法冠心病介入治疗组(PCI组)36例和单纯冠脉造影组(CAG组)28例,在术前、术后3 h、6 h、12 h、24 h以及48h分别测定血清AIF、Cyt-C及Apaf-1水平。结果术前PCI组与CAG组的AIF、Cyt-C水平差异均有统计学意义,而术前PCI组与CAG组的Apaf-1水平差异无统计学意义。PCI组术后AIF、Cyt-C及Apaf-1水平较术前有升高趋势,在术后12 h达高峰,以后逐渐恢复至基线水平,但各时间点水平差异无统计学意义。CAG组术后血浆AIF、Cyt-C及Apaf-1水平较术前有升高趋势,至术后48 h达到峰值,AIF术后48 h水平与术前相比差异具有统计学意义(P<0.05)。PCI组与CAG组术后各时间点AIF、Cyt-C与Apaf-1水平相比均显著增高,于术后12 h AIF、Cyt-C与Apaf-1水平PCI和CAG两组之间的差异均具有统计学意义,且AIF术后6 h、24 h水平PCI和CAG两组之间的差异均具有统计学意义。结论 PCI可引起血AIF、Cyt-C及Apaf-1水平升高,PCI组术前AIF、Cyt-C及Apaf-1水平明显高于CAG组,提示冠状动脉病变程度与细胞凋亡呈正相关。冠脉介入治疗术后可能出现短暂性心肌缺血,加重了心肌损伤,AIF、Cyt-C及Apaf-1可作为细胞凋亡的监测指标并有助于冠心病患者PCI术后不典型心肌损伤的诊断。AIF可能是反映细胞损伤的敏感指标之一。
Objective By patients with coronary artery disease before and after interventional treatment in serum apoptosis-inducing factors（AIF）,cytochrome C（C）,Cyt-C apoptosis protease activated factor（Apaf-1） level changes,coronary interention（PCI） in patients with coronary artery disease,Cyt-C AIF serum and Apaf-1.Methods Perc-Utaneous coronary intervention（PCI） 36 cases and pure coronary angiography CAG group（group）,28 cases in pre-operative and postoperative 3 h,6 h 12 h and 24 h,determination and 48 h AIF serum Cyt-C,Apaf-1 and level.Result Preoperative group and the group of PCI and CAG AIF,Cyt-C levels were statistically significant difference,while preoperative PCI group and the group Apaf-1 CAG level difference was statistically significant.PCI group,Cyt-C and AIF Apaf-1 level,had a preoperative 12h reach peak in postoperative recovery,later to baseline,but each time point level difference was statistically significant.AIF plasma CAG after group Cyt-c Apaf-1 and there was increased,preoperative and postoperative 48 h peak AIF 48h level compared with the preoperative after a statistically significant difference（P0.05）.PCI groups and different time points CAG group,Cyt-C AIF Apaf-1 with all levels were sign-ificantly higher in surgery,Cyt-C12 h AIF,with Apaf-1 level CAG PCI and differences between the two groups was statistically significant,and postoperative 6 h AIF 24 h CAG PCI and level,differences between the two groups was sta-tistically significant.Conclusion The PCI can cause blood AIF,Cyt-C and Apaf-1 levels,PCI group,Cyt-C AIF preoperative and Apaf-1 level CAG group was obviously higher than that of coronary artery disease extent hints are positive correlated with cell apoptosis.After coronary interention may appear transient ischemia,increase cardiac injury Cyt-C and AIF,Apaf-1 as apoptosis of monitoring index PCI and help patients with coronary artery disease is not typical of myocardial injury after diagnosis.AIF may be reflected the sensitive cell damage indexes.
出处
《临床和实验医学杂志》
2011年第4期246-248,共3页
Journal of Clinical and Experimental Medicine
