摘要
目的探讨负荷剂量氯吡格雷治疗非心源性急性脑梗死的疗效。方法 将242例非心源性急性脑梗死患者随机分为负荷组120例(给予氯吡格雷首剂300mg,之后改为75mg/d)和标准组122例(给予氯吡格雷75mg/d),均连用14d。治疗后比较2组卒中量表(NHISS)评分、凝血指标、血常规及药物不良反应。结果 2组治疗后NHISS评分均低于治疗前,差异有统计学意义(P<0.05);且负荷组治疗后NHISS评分低于标准组,差异有统计学意义(P<0.05)。2组治疗前后凝血指标差异无统计学意义(P>0.05)。2组均未发生危及生命的中枢神经系统出血及严重的皮肤黏膜出血,对血液系统均无明显影响(P>0.05)。结论 负荷剂量氯吡格雷治疗非心源性急性脑梗死疗效优于常规剂量,且无明显安全性问题,值得临床进一步推广。
Objective To discuss the effect of clopidogrel of loading dose in non-cardiac acute infarction.Methods 242 cases patients with non-cardiac acute infarction were randomly divided into load group（120 cases）（were given clopidogrel of the first dose 300mg,followed to 75mg/d）and standard group（122 cases）（were given clopidogrel 75mg/d）,all followed up for 14d.After treatment,compared the NHISS score,coagulation of the blood system and adverse drug reactions of two groups.Results After treatment,the NHISS score of two group were significantly decreased（P0.05）;And the NHISS score of load group were lower than that of the standard group（P0.05）.Coagulation of the blood system before and after treatment of two groups were no significant difference（P0.05）.No life-threatening occurrence of bleeding and severe central nervous system,skin and mucous membrane bleeding of two groups happened,had no significant effect on the blood system（P0.05）.Conclusion Clopidogrel of loading dose in non-cardiac acute infarction is safe and effective,and is worth to use by clinical internal medical doctor.
出处
《临床合理用药杂志》
2011年第1期1-3,共3页
Chinese Journal of Clinical Rational Drug Use
基金
河北省科技厅攻关项目立项(No:062761361)
