摘要
目的:观察非小细胞肺癌行三维适形低分割高剂量放射治疗的疗效与并发症,探讨适合的分割模式和照射剂量。方法:回顾性分析682例非小细胞肺癌,采用三维适形放射治疗,90%-95%的剂量曲线覆盖PTV,单次分割剂量5Gy,1次/日或隔日,3-5次/周,DT50-70Gy/10-14次,中位照射剂量60Gy/12次,等效生物剂量88-90Gy。结果:682例患者中,完全缓解(CR)87例(12.8%),部分缓解(PR)561例(82.2%),总有效率(CR+PR)为95%,其中III级以上放射性肺炎发生率5.2%(36/682),未出现明显的放射性食管炎。结论:非小细胞肺癌采用三维适形低分割高剂量放射治疗(5Gy/次,每周3-5次,中位照射剂量60Gy/12次),是相对安全的;而且局部控制率高,有较好的近期疗效,并发症低,值得推广使用。
Objective： To analyze the curative effects and side effects of three dimensional conformal hypofractionated high dose radiotherapy（3DCRT） for non small cell lung cancer（ NSCLC）, to explore the fraction and the dose in NSCLC treatment. Methods： To review and analyse the data of 682 NSCLC patients treated by 3DCRT, PTV was covered by the dose of 90% -95%, the fraction dose was 5Gy. They were treated once a day or once two days, 3 -5 times/week, DT 50 - 70Gy/10 - 14 times, the median dose 60Gy/12F. Results ： Of 682 NSCLC patients, complete remission in 87 cases and partial remission in 561 cases, the overall remission （CR ＋ PR） rate was 95%. Severe early radiation injuries were observed in 36 cases, radiation pneumonitis in grade III, and no obvious rradiation esophagitis occurred. Conclusion： 3 DCRT could be used for NSCLC because it is safe, higher local control rate and lower side effects.
出处
《现代肿瘤医学》
CAS
2011年第2期283-285,共3页
Journal of Modern Oncology
