摘要
目的:观察合成红藻氨酸(SKA)诱发大鼠癫痫的作用及其作用特点。方法:Wistar大鼠40只,随机分为正常对照组、SKA12 mg/kg、SKA10 mg/kg和SKA5 mg/kg剂量组及红藻氨酸(KA)10 mg/kg阳性对照组。腹腔注射给药,连续8 h观察大鼠癫痫发作的行为学变化及连续3.5 h记录其脑电图变化。结果:合成红藻氨酸5、10、12 mg/kg腹腔注射,可诱发大鼠癫痫发作,其行为学及脑电改变与KA对照组无明显差异。但合成红藻氨酸诱发动物癫痫呈现规律、稳定及阶段性明显的特征,且大鼠的死亡率较天然红藻氨酸低。结论:合成红藻氨酸腹腔注射可诱发大鼠癫痫发作,以10 mg/kg为较合适剂量。
AIM：To observe the effect of synthetical kainic acid（SKA） on inducing epileptic seizure in rats.METHODS：Forty Wistar rats were divided into normal control group,5 mg/kg,10 mg/kg and 12 mg/kg SKA-treated groups and kainic acid（KA） positive control group.The SKA was injected intraperitoneally.The changes of the epileptic behaviors were observed for 8 h successively and the electroencephalography was recorded for 3.5 h.RESULTS：SKA induced epileptic seizures at the dose of 5-12 mg/kg by intraperitoneal injection.No apparently difference between SKA and KA on the changes of epileptic behaviors or electroencephalography was observed.However,the epileptic seizure induced by SKA showed obvious stages,regular pattern and action steady.In addition,SKA caused lower fatality than KA did.CONCLUSION：SKA induces epileptic seizure in rats and the dose of 10 mg/kg by intraperitoneal injection is the optimal.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2011年第1期204-208,共5页
Chinese Journal of Pathophysiology
关键词
合成红藻氨酸
模型
癫痫
Synthetic kainate acid
Models
epilepsy
