摘要
运用循环伏安法(CV)、计时电流法(CA)和计时电量法(CC)研究了延胡索酸泰妙菌素(Tiamulin fumarate,TF)在碳糊电极(Carbon Paste Electrode,CPE)上的电化学及其电化学动力学性质。结果表明,TF在CPE上的电化学过程是一不可逆的氧化过程,氧化峰电位Ep为0.772 V。在扫描速度10～1 000 mV.s-1范围内,其氧化峰电流Ip与扫描速度v呈良好的线性关系,表明TF在CPE上的伏安行为是一受吸附控制的过程。方波伏安(SWV)法结果表明TF氧化峰电流与其浓度在5.0×10-7～1.0×10-5mol.L-1及1.0×10-5～1.0×10-4mol.L-1范围内均呈良好的线性关系,相关系数r分别为0.9980及0.9966,检出限(S/N=3)为5.8×10-8mol.L-1,相对标准偏差(RSD)为0.8%～2.8%,加样回收率为97.6%～102.0%。据此建立了TF含量的电化学测定方法。该方法简便快捷,测定结果令人满意。
Electrochemical behaviors of tiamulin fumarate（TF） at carbon paste electrode（CPE） and its electrochemical kinetic parameters have been investigated by cyclic voltammetry（CV）,chronoamperometry（CA） and chronocoulometry（CC）.Electrochemical experimental results showed that the electrochemical behavior of TF in 0.10 mol·L-1 phosphate buffer solution（PBS） exhibited an irreversible electrochemical oxidation process at CPE,and the oxidation peak potential（Ep） was 0.772 V.The plot of oxidation peak currents versus the scanning rates in the potential range of 10～1 000 mV·s-1 showed a straight line,as expected for a adsorption controlled electrochemical process.The changes of the oxidation peak currents with TF concentration were examined by square wave voltammetry（SWV）.The oxidation peak currents versus TF concentration had a good linear relationship in the concentration range of 5.0×10-7～1.0×10-5 mol·L-1 and 1.0×10-5～1.0×10-4 mol·L-1,with the correlation coefficient of 0.9980 and 0.9966 respectively,and the detection limit of 5.8×10-8 mol·L-1 was obtained for TF by SWV response.The relative standard deviation was 0.8%～2.8% and the recoveries were in the range of 97.6%～102.0%.The proposed method could be applied in the determination of TF in real tablet samples.
出处
《分析科学学报》
CAS
CSCD
北大核心
2011年第1期40-44,共5页
Journal of Analytical Science
基金
宁夏高等学校科学研究基金(200623)
关键词
延胡索酸泰妙菌素
碳糊电极
电化学性质
电分析方法
Tiamulin fumarate
Carbon paste electrode
Electrochemistry
Electrochemical determination
