摘要
目的 探讨胃粘膜病变中p16、p21、p53 蛋白、cyclinD1和PCNA表达异常的意义。方法 免疫组织化学(S- P)方法和显微摄像计算机图象分析技术。结果 227 例胃粘膜病变中p16 阳性152 例(66.9% );p21阳性135 例(59.5% );p53阳性25例(11.0% );cyclinD1 阳性97 例(42.7% )。结论 提示p16、p21 蛋白的低表达和p53 蛋白、cyclinD1的过表达在胃粘膜细胞增殖癌变过程中起重要作用。
? Objectives To study the significance of expressions of p16,p21,p53,PCNA in the disease of gastric mucosa.Methods By using S-P immunohistochemical methods and the image analyzing system in computer.Results The positive expressions of p16,p21,p53 and cyclinD1 were 66.9%,59.5%,11.0% and 42.7% in 227 cases of gastric mucosa disease respectively.Conclusions The results showed that low p16,p21 expression and cyclinD1,p53 overexpression played an important role in cell proliferation of gastric mucosa. 〔
出处
《中国肿瘤临床与康复》
1999年第4期7-8,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胃粘膜
基因
增殖细胞核抗原
周期蛋白
免疫组织化学
Gastric mucosa
Gene
Proliferating cell nuclear antigen
Cyclin
Immunohistochemistry