联合cTnT、hs-CRP、NT-ProBNP测定对心力衰竭的诊断及预后判断的意义被引量：27

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摘要目的探讨心肌肌钙蛋白T(cTnT)、高敏C反应蛋白(hs-CRP)和B型钠尿肽前体(NT-ProBNP)联合检测对心力衰竭诊断和预后判断的价值。方法测定115例明确诊断为CHF的不同病因、不同心功能分级的患者入院时、出院时血清cTnT、hs-CRP和血浆NT-ProBNP水平,进行治疗前后对比观察,并与30名健康对照组比较,随访观察患者心脏事件再发生的情况。结果血清cTnT、hs-CRP和血浆NT-ProBNP水平在CHF患者不同心功能分级组和对照组之间差异均有统计学意义,且心功能越差,其浓度越高(均P<0.01);三者在CHF患者治疗前后比较,差异均有统计学意义(均P<0.01);三者联合检测在CHF患者早期敏感性为78.3%,明显优于单项检测(均P<0.01);出院后发生心脏事件组血清cTnT、hs-CRP和血浆NT-ProBNP出院时浓度明显高于未发生心脏事件组(均P<0.01)。结论血清cTnT、hs-CRP和血浆NT-ProBNP在CHF患者中明显升高,三者联合检测对CHF临床诊断和预后判断有应用意义。

作者刘路平谢晓林林玎

机构地区杭州市第三人民医院

出处《心脑血管病防治》 2011年第1期40-42,共3页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

关键词肌钙蛋白T 高敏C反应蛋白 B型钠尿肽前体心力衰竭预后判断

分类号 R541.6 [医药卫生—心血管疾病] R446 [医药卫生—诊断学]

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