摘要
目的了解滨州市流动人口的结核病耐药状况及相关因素。方法将滨州市各区县结核病定点医院2004年2月至2005年1月诊治的流动人口中所有新发及复治的痰培养阳性肺结核病例作为研究对象,并对所有分离培养阳性菌株进行菌型鉴定及药物敏感性测试,分析流动人口耐药结核病的流行状况。结果所入选493例培养阳性肺结核患者,最后获得431例(占87.4%)患者的菌型鉴定及药敏结果,其中结核分枝杆菌427例(占99.1%),非结核分枝杆菌4例(占0.9%)。肺结核患者的总耐药率为18.3%(78/427),耐多药率为5.9%(25/427);新发患者的耐药率为16.0%(62/387),耐多药率为4.1%(16/387);复治患者的耐药率为40.0%(16/40),耐多药率为22.5%(9/40)。结论滨州市流动人口的结核病耐药率较高,要加强防治措施。
Objective To determine the prevalence of and risk factors for drug-resistant tuberculosis among migratory population in Binzhou.Methods All aputum culture positive patients among migratory population,confirmed at any district（county） tuberculosis dispensary in binzhou from February 2004 to January 2005,were enrolled.The drug susceptibility test was performed by the proportion method.Unvariate and multivariate analysis were preformed to determine the risk factors associated with drug resistance.Results 493 patients were enrolled during the study period,among whom 431patients had bacteria identification and drug susceptibility results.Of the 431 strains,427（99.1%） strains were Mycobacterium tuberculosis and 4（0.9%） strained were Mycobacterium non-tuberculosis.The prevalence of drug-resistant tuberculosis among new cases ang retreatment cases was 16.0%（62/387）and 40.0%（16/40）,respectively.The prevalence of MDR-tubercuolsis among new cases and re-treatment cases was 4.1%（16/387）and 22.5%（9/40）,respectively.A history of previous treatment for tuberculosis and age group of 45~60 years were significantly associated with drug resistance.Conclusion The prevalence of drug-resistant tuberculosis among migratory population was relatively high in Binzhou,suggesting the necessity to strengthen the tuberculosis control program for migratory population.
出处
《临床肺科杂志》
2011年第3期407-409,共3页
Journal of Clinical Pulmonary Medicine
关键词
结核
肺
居住流动性
抗药性
危险因素
tuberculosis
pulmonary
residential mobility
drug resistance
risk factors
