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首发重症抑郁症的弥散张量成像研究:基于纤维束示踪的空间统计学分析结果 被引量:6

Investigation of White Matter with Tract-based Spatial Statistics in Patients with Major Depressive Disorder
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摘要 目的:应用基于纤维束示踪的空间统计分析(Tract-Based Spatial Statistics,TBSS)方法,探讨重症抑郁症病患者全脑白质纤维的完整性是否受到损害。方法:对20(8男,12女)例重症抑郁症病患者组和20(8男,12女)例与抑郁症组按性别、年龄、教育程度匹配的正常人进行全脑弥散张量成像扫描。应用TBSS方法来比较两组的各向异性分数。结果:抑郁症组的左侧内囊前肢、右侧海马旁回、左侧后扣带回的各向异性分数显著低于正常组(P<0.05,t>3,校正),患者组内囊前肢的各向异性分数和抑郁症严重程度呈现负相关。结论:白质病变在抑郁症发病早期即已存在,这些病变区域主要涉及前额叶和边缘系统等与认知和情感调节关系较密切的神经环路的纤维束,这些改变可能导致皮层和皮层下连接受损,从而有利于深入了解抑郁症疾病的发病机理。 Objective:The present study aimed to evaluate changes of white matter in patients with major depressive disorder(MDD) by use of a novel method called Tract-Based Spatial Statistics(TBSS).Methods:Diffusion tensor imaging(DTI) was performed in 20 patients with MDD and 20 healthy controls.TBSS was used to analyze the DTI data.Results:Compared with healthy controls,fractional anisotropy(FA) values were significantly decreased in the white matter of the left anterior limb of the internal capsule(ALIC),the right parahippocampal gyrus and the left posterior cingulate cortex.Further analysis revealed that FA values in the ALIC were negatively correlated with the severity of depressive symptoms.Conclusion:The present results support the hypothesis that altered WM integrity,especially in the cortical-subcortical neural circuit,may contribute to the pathophysiology of MDD.Furthermore,these findings provide novel evidence that microstructural abnormalities in WM may occur early in the course of depression.
出处 《中国临床心理学杂志》 CSSCI CSCD 2011年第1期1-3,共3页 Chinese Journal of Clinical Psychology
基金 国家自然科学基金(3067070930700236)
关键词 重症抑郁症 弥散张量成像 白质 各向异性 Major depressive disorder Diffusion tensor imaging White matter Fractional anisotropy
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参考文献16

  • 1Sexton CE, Mackay CE, Ebmeier KP. A systematic review of diffusion tensor imaging studies in affective disorders. Biol Psychiatry, 2009, 66:814-823.
  • 2Smith SM, Jenkinson M, Johansen-Berg H, et al. Tract- based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage, 2006, 31:1487-1505.
  • 3Rogers MA, Bradshaw JL, Pantelis C, Phillips JG. Frontos triatal deficits in unipolar major depression. Brain Res Bull, 1998, 47:297-316.
  • 4Tekin S, Cummings JL. Frontal-subcortical neuronal circuits and clinical europsychiatry: An update. J Psychosom Res, 2002, 53:647-654.
  • 5Axer H, Keyserlingk DG. Mapping of fiber orientation in human internal capsule by means of polarized light and confocal scanning laser microscopy. J Neurosci Meth, 2000, 94:165-175.
  • 6Zou K, Huang X, Li T, Gong Q, et al. Alterations of white matter integrity in adults with major depressive disorder: A magnetic resonance imaging study. J Psychiatry Neurosci, 2008, 33:525-530.
  • 7Werner NS, Meindl T, Materne J, et al. Functional MRI study of memory-related brain regions in patients with depressive disorder. J Affect Disord, 2009, 119:124-131.
  • 8Abe O, Yamasue H, Kasai K, et al. Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression. Psychiatry Res, 2010, 181:64-70.
  • 9Drevets W. Neuroimaging and neuropathological studies of depression: Implications for the cognitive emotional manifestations of mood disorder. Current Opinion in Neurobiology, 2001, 11:240-249.
  • 10Vogt BA, Vogt L, Laureys S, et al. Cytology and functionally correlated circuits of human posterior cingulate areas. Neuroimage, 2006, 29:452-466.

同被引文献77

  • 1侯庆.心理应激、脑海马损伤与抑郁症[J].中国临床康复,2005,9(32):174-176. 被引量:19
  • 2Ebmeier KP, Donaghey C, Steele JD. Recent developments and current controversies in depression. Lancet, 2006, 367 (9505): 153-167.
  • 3Sexton CE, Le Masurier M, Allan CL, et al. Magnetic reso- nance imaging in late-life depression: Vascular and gluco- corticoid cascade hypotheses. Br J Psychiatry, 2012, 201(1): 46-51.
  • 4Welch JM, Lu J, Rodriguiz RM, et al. Cortico-striatal syn- aptic defects and OCD-like behaviours in Sapap 3-mutant mice. Nature, 2007, 448(7156): 894-900.
  • 5Marchand WR, Lee JN, Suchy Y, et al. Aberrant functional connectivity of cortico-basal ganglia circuits in major de- pression. Neurosci Lett, 2012, 514(1): 86-90.
  • 6Cheng YQ, Xu J, Chai P, et al. Brain volume alteration and the correlations with the clinical characteristics in drug- naive first-episode MDD patients: A voxel-based morpho- merry study. Neurosci Lett, 2010, 480(1): 30-34.
  • 7Abe O, Yamasue H, Kasai K, et al. Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression. Psychiatry Res, 2010, 181(1): 64-70.
  • 8Nobuhara K, Okugawa G, Sugimoto T, et al. Frontal white matter anisotropy and symptom severity of late-life depres- sion: A magnetic resonance diffusion tensor imaging study. J Neurol Neurosur Psychiatry, 2006, 77(1): 120-122.
  • 9Sexton CE, Le Masurier M, Allan CL, et al. Magnetic reso- nance imaging in late-life depression: Vascular and gluco- corticoid cascade hypotheses. The British Journal of Psychi- atry, 2012, 201(1): 46-51.
  • 10Wedeen V J, Wang RP, Schmahmann JD, et al. Diffusion spectrum magnetic resonance imaging(DSI) tractography of crossing fibers. Neuroimage, 2008, 41(4): 1267-1277.

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