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幂型自相关指数定量化评价帕金森病运动障碍特异性的研究 被引量:4

The Specificity of Power-law Exponent to Evaluate the Severity of Movement Disorder for Parkinson's Disease
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摘要 目的:研究便携式加速度记录定量化评价帕金森病(PD)患者运动障碍程度的特异性。方法:61例PD患者根据国际治疗指南接受常规治疗,于治疗前与治疗后(30~60d后)将便携式加速度记录仪佩戴于患者利手侧手腕连续记录6d。同时利用帕金森病统一评分量表(UPDRS)评价治疗前后PD患者的临床评分;同时解析加速度记录仪记录的身体活动数据,评价PD患者治疗前后的幂型自相关指数(PLE)的变化,分析UPDRS评分与PLE的相关性。结果:与治疗前比较,治疗后PD患者的UPDRS评分以及PLE值均显著改善(P<0.05),PLE改善率与UPDRS评分以及运动障碍部分(PartⅢ)评分的改善率呈直线相关(分别r=0.794和0.823,P<0.01);结论:利用PLE解析加速度记录仪所记录的身体运动可以用于客观定量化评价PD运动障碍的程度,有较高的特异性,可作为PD患者门诊疗效评价的工具。 Aim:To evaluate a specific,objective scale representing disease severity for appropriate management of patients with Parkinson's disease (PD). Methods:61 patients with PD were treated according to the international medication guiding principle for PD treatment. Every patient wore a actigraph for 6 days before and 30-60 days after the treatment separately. The power-law exponent (PLE) recorded were analyzed,which corresponded to the levels of patients physical activity. Drug efficacy was evaluated with the conventional Unified Parkinson Disease Rating Scale (UPDRS) for PD. The changes of PLE were evaluated before and after the treatment and their relations with the improvements of UPDRS scores were analyzed. Results:Both the UPDRS scores and the PLE values for the PD patients were improved obviously after the drug administration,which yielded a liner correlation coefficient of 0.794 and 0.823 between the improvements of total UPDRS scores and the PLE values,the UPDRS Part III and the PLE values respectively (P0.01).
出处 《中国临床神经科学》 2011年第1期5-8,共4页 Chinese Journal of Clinical Neurosciences
基金 上海浦江人才计划(编号:09PJ1409300)
关键词 帕金森病 运动障碍 定量化评价 幂型自相关指数 特异性 Parkinson's disease movement disorder quantitative assessment power-law exponent specificity
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参考文献13

  • 1Martinez-Martin P,Gil-Nagel A,Gracia LM,et al.Unified Parkinson's Disease Rating Scale characteristics and structure.The Cooperative Multicentric Group[J].Mov Disord,1994,9:76-83.
  • 2Pan W,Ohashi K,Yamamoto Y,et al.Power-law temporal autocorrelation of activity reflects severity of parkinsonism[J].Mov Disord,2007,22:1308-1313.
  • 3Pan W,Soma R,Kwak S,et al.Improvement of motor functions by noisy vestibular stimulation in central neurodegenerative disorders[J].J Neurology,2008,255:1657-1661.
  • 4潘卫东,方正龙,刘云,支惠萍.身体活动的幂型自相关指数定量化反映帕金森病的程度[J].中国临床神经科学,2010,18(3):257-262. 被引量:8
  • 5蒋雨平,王坚,丁正同,邬剑军,陈嬿.原发性帕金森病的诊断标准(2005年)[J].中国临床神经科学,2006,14(1):40-40. 被引量:156
  • 6Ohashi K,Nunes Amaral LA,Natelson BH,et al.Asymmetrical singularities in real-world signals[J].Phys Rev E Stat Nonlin Soft Matter Phys,2003,68:065204.
  • 7Sekine M,Akay M,Tamura T,et al.Fractal dynamics of body motion in patients with parkinson's disease[J].J Neural Eng,2004,1:8-15.
  • 8Olanow CW,Watts RL,Koller WC.An algorithm (decision tree) for the management of Parkinson's disease (2001):treatment guidelines[J].Neurology,2001,56:1-88.
  • 9Peng CK,Havlin S,Stanley HE,et al.Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series[J].Chaos,1995,5:82-87.
  • 10Struzik ZR,Hayano J,Soma R,et al.Aging of complex heart rate dynamics[J].IEEE Trans Biomed Eng,2006,53:89-94.

二级参考文献35

  • 1董青,李焰生.帕金森病非运动症状的研究进展[J].临床神经病学杂志,2008,21(4):310-312. 被引量:32
  • 2蒋雨平,王坚,丁正同,邬剑军,陈嬿.原发性帕金森病的诊断标准(2005年)[J].中国临床神经科学,2006,14(1):40-40. 被引量:156
  • 3安星凯,彭蓉,吴妍.帕金森病患者睡眠障碍的评价及其治疗策略[J].中国临床康复,2006,10(18):116-118. 被引量:6
  • 4沈伟,袁灿兴.滋补肝肾为主治疗帕金森病的疗效观察[J].上海中医药杂志,2006,40(6):21-22. 被引量:16
  • 5Martinez-Martin P,Gil-Nagel A,Gracia LM,et al.Unified parkinson's disease rating scale characteristics and structure.The cooperative multicentric group[J].Mov Disord,1994,9:76-83.
  • 6Katayama S.Actigraph analysis of diurnal motor fluctuations during dopamine agonist therapy[J].Eur Neurol,2001,46:11-17.
  • 7Korte J,Hoehn T,Siegmund R.Actigraphic recordings of activity-rest rhythms of neonates born by different delivery modes[J].Chronobiol Int,2004,21:95-106.
  • 8van Someren EJ,Hagebeuk EE,Lijzenga C,et al.Circadian rest-activity rhythm disturbances in Alzheimer's disease[J].Biol Psychiatry,1996,40:259-270.
  • 9Okawa M,Mishima K,Hishikawa Y,et al.Rest-activity and body-temperature rhythm disorders in elderly patients with dementia--senile dementia of Alzheimer's type and multi-infarct dementia[J].Rinsho Shinkeigaku,1995,35:18-23.
  • 10Teicher MH.Actigraphy and motion analysis:New tools for psychiatry[J].Harv Rev Psychiatry,1995,3:18-35.

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