摘要
目的探讨葡萄糖转运蛋白Ⅰ型(glucose transporter 1,GLUT1)和肿瘤增殖细胞核抗原Ki-67在卵巢上皮性肿瘤组织中的表达及其临床意义。方法收集2000年1月2008年6月不同卵巢上皮性肿瘤病变患者119例的组织标本,采用免疫组织化学SP二步法检测肿瘤组织中GLUT1和Ki-67的表达情况。结果卵巢交界性、恶性上皮性肿瘤灶性或广泛高表达GLUT1和Ki-67,其表达强度有差异。卵巢良性上皮性肿瘤不表达GLUT1和Ki-67。在卵巢癌中GLUT1及Ki-67的表达强度与病理分级、临床分期、预后有关。GLUT1表达强度与病理分型无关,Ki-67表达强度与病理分型有关。结论卵巢上皮性肿瘤组织中GLUT1和Ki-67的表达具有相关性,其表达强度与肿瘤的良恶性质和增殖状态有关,二者同时检测可以全面了解卵巢上皮性肿瘤的性质、卵巢癌恶性程度和生物学行为,对于判断肿瘤的性质和预后有一定价值。
Objective To investigate the expression and clinical significance of glucose transporter-1（GLUT1） and tumor proliferating karyon antigen Ki-67 in epithelial ovarian tumor tissue.Methods Immunohistochemistry SP method was used to detect the expression of GLUT1 and Ki-67 protein in epithelial ovarian tumor tissues from 119 patients diagnosed in our hospital from January 2000 to June 2008.Results The expressions of GLUT1 and Ki-67 had local or abroad higher expressions in the borderline and malignant epithelial ovarian tumor,and the expressive intensity was different.In benign tumors,the expression was negative.The expressive intensity of GLUT1 and Ki-67 had correlation with the grade,stage,and prognosis in malignant tumors.The expressive intensity of GLUT1 had no correlation with the type of malignant tumors,while Ki-67 related to the pathological types.Conclusion The expressions of GLUT1 and Ki-67 have relativity.The expressive intensity of GLUT1 and Ki-67 relates to the character and proliferation of epithelial ovarian tumors.The combined detection GLUT1 and Ki-67 is helpful to know the character of epithelial ovarian tumors,the malignant degree and biologic behavior of ovarian carcinoma,which is useful in estimating the character and prognosis of epithelial ovarian tumors.
出处
《华西医学》
CAS
2011年第1期63-65,共3页
West China Medical Journal
