摘要
目的:比较4种床旁检验(Point-of-caretesting,POCT)血糖仪的主要性能。方法:选取高、中、低不同葡萄糖浓度的新鲜肝素抗凝全血,在强生、罗氏、雅培、瑞特4种型号POCT血糖仪组成的检测系统上测定,进行精密度评价;同时对4种血糖仪的回收率、线性、干扰、压积影响等方面进行评价,生化仪静脉血糖结果和血糖仪静脉血、指血结果的比较。结果:4种检测系统批内精密度符合要求(CV<10%);回收率均在90%～110%内;罗氏血糖仪测定线性最好,抗血红蛋白能力较强,但受抗坏血酸影响较大;血细胞压积对罗氏血糖仪影响较小,其余3种血糖仪均随压积的增加而明显降低;半乳糖和木糖分别影响强生、雅培血糖仪测定结果;除瑞特血糖仪外,其余3种血糖仪静脉血结果高于生化仪结果(P<0.05),雅培血糖仪指血糖结果明显高于生化仪静脉血血糖结果(P<0.05),其余3种无明显差别。胆红素、甘油三脂、果糖、麦芽糖、蔗糖对4种血糖仪测定血葡萄糖结果无明显影响。结论:4种型号POCT血糖仪的检测性能各具局限性,在临床用于患者血糖水平的监测时,应该引起足够重视,充分了解它们各自的性能以更好地对糖尿病防治起到积极的指导作用。
Objective：To evaluate the main performance for four types of POCT blood glucose meters.Methods：Fresh heparinized blood samples with high,medium,low glucose concentration were detected by four types of POCT blood glucose meters（Johnson Johnson,Roche,Abbott,and Reiter）.The degree of precision,the rate of recovery,linearity,interference,and hematocrit effect for the four types of blood glucose meters were evaluated.The results of venous blood glucose determined by biochemical analyzer and the results of venous blood,finger blood of blood glucose meter were compared.Results：Degree of precision for four detecting systems meets the requirement（CV10%）;all the rates of recovery are in the scope of 90%～110%.The linearity of Roche blood glucose meter is the best of all with high ability of anti-hemoglobin effect,but influenced greatly by ascorbic acid.Hematocrit has less impact on Roche blood glucose meters,while in the other three types of blood glucose meters,it is significantly reduced with the increase of hematocrit reading.The measured results of Johnson Johnson,Roche,Abbott blood glucose meter are affected by galactose and xylose respectively.The results of other three types of blood glucose meters are higher than the result of biochemical analyzer（P0.05） except for Reiter blood glucose meters.Results of finger blood glucose determination by Abbott blood glucose meters are higher than the result of venous blood glucose determination by biochemical analyzer（P0.05）,but no difference was found with other three types of meters.Bilirubin,triglycerides,fructose,maltose,sucrose have no significant effect on the result of blood glucose as tested by four kinds of blood glucose meters.Conclusion：There are limitations for detection performance of four types POCT glucose meters.Sufficient attention should be paid in clinical monitoring of blood glucose levels for patients.Thus fully understand their characteristics in order to better prevent and treat diabetes in guidance.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2011年第1期68-72,共5页
Journal of Chongqing Medical University
关键词
床旁检验
血糖仪
性能比较
POCT
blood glucose meters
performance comparison
