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高度复杂核型多发性骨髓瘤1例报道并文献复习

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摘要 多发性骨髓瘤（multiple myeloma,MM）是骨髓浆细胞的恶性疾病,以产生单克隆免疫球蛋白为特征,常伴有骨痛、贫血和肾功能不全。MM占血液系统肿瘤的10%,〉60岁老年患者多见[1]。研究结果[2-3]发现,细胞遗传学异常与MM的发生、治疗方案的选择及预后密切相关。本文结合文献分析1例复杂核型MM患者的临床资料,报道如下。
作者 殷杰 孙爱红 姜扬文
机构地区 苏北人民医院血液科
出处 《中华实用诊断与治疗杂志》 2011年第2期207-208,共2页 Journal of Chinese Practical Diagnosis and Therapy
关键词 多发性骨髓瘤 硼替佐米 复杂染色体异常
分类号 R733.3 [医药卫生—肿瘤]
  • 相关文献

参考文献12

  • 1Collins C D. Multiple myeloma[J]. Cancer Imaging, 2004, 4: S47-S53.
  • 2Gutierrez N C, Hernandez J M, Garcia J L, et al. Correlation between eytogenetic abnormalities and disease characteristic in multiple myeloma: monosomy of chromosome 13 and structural abnormalities of llq are associated with a high percentage of S-phase plasma cells[J]. Haematologica, 2000,85 ( 11 ) : 1146-1152.
  • 3张艳,江滨,黄晓军,师岩,何琦,党辉,邱镜滢,陆道培.多发性骨髓瘤的细胞遗传学研究[J].中国实验血液学杂志,2007,15(1):76-78. 被引量：20
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二级参考文献8

  • 1Debes-Marum CS, Dewald GW, Bryant S, et al. Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma. Leukemia, 2003 ; 17:427 - 436
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  • 4Avet-Loiseau H, Facon T, Grosbois B, et al. Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation. Blood, 2002; 99:2185-2191
  • 5Zojer N, Konigskerg R, Ackermann J, etal. Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization. Blood, 2000; 95: 1925- 1930
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  • 7佟刚,魏素芳.多发性骨髓瘤的细胞遗传学研究进展[J].国外医学（输血及血液学分册）,1990,13(3):137-139. 被引量：3
  • 8丘镜滢,党辉,任汉云,王德炳,段爱君.自体血浆培养体系对改善白血病骨髓细胞染色体的研究[J].北京医科大学学报,1993,25(4):249-251. 被引量：46

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中华实用诊断与治疗杂志
2011年 第2期

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