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冠心病患者OX40配体蛋白基因多态性的研究 被引量:1

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摘要 目的:探讨中国重庆地区汉族人群OX40配体蛋白基因(TNFSF4)单核苷酸多态性与冠心病的关系。方法:提取262例冠心病患者和191例对照者的基因组DNA,采用Taqman实时荧光定量PCR法检测TN-FSF4 rs3850641(A/G)单核苷酸多态性。结果:重庆地区汉族人群中存在TNFSF4 rs3850641(A/G)单核苷酸多态性,冠心病组中基因型分布为:AA型70.5%,AG型22.0%、GG型7.5%;对照组基因型分布为:AA型69.8%,AG型20.8%、GG型9.4%。冠心病组和对照组之间的基因型频率和等位基因频率均差异无统计学意义(P>0.05)。结论:OX40L基因rs3850641(A/G)单核苷酸多态性与中国重庆地区汉族人群冠心病发病无关。
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2010年第12期955-957,共3页 Journal of Clinical Cardiology
基金 重庆医科大学基金资助(No:XBYB2008019)
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