摘要
目的探讨原发性中枢神经系统血管炎(PACNS)的临床及病理学特点。方法回顾性分析1例PACNS患者的临床资料。结果该患者临床表现为癫发作及左侧肢体无力;头颅MRI显示右额顶叶长T1、长T2异常信号;脑活检可见小动脉炎性细胞浸润,管腔狭窄。糖皮质激素及环磷酰胺治疗6个月,临床表现及MRI未见明显改变。结论 PACNS的临床表现无特异性,脑组织活检对诊断具有重要意义。
Objective To investigate the clinical and pathological features of primary angiitis of the central nervous system（PACNS）.Methods The clinical data of a PACNS patient were analyzed retrospectively.Results This case presented seizure and weakness of left limbs.Cerebral MRI showed long T1 and T2 abnormal signals in right fronta-pareital lobe.Brain biopsy showed that the arterioles were infiltrated by inflammatory cells and the luminal was stenosis.After treatment with glucocorticoid and cyclophosphamide for 6 months,there was no significant change in clinical manifestation and cerebral MRI.Conclusion The clinical manifestation of PACNS is no specificity,and brain biopsy plays an important role in diagnosis.
出处
《临床神经病学杂志》
CAS
北大核心
2010年第6期464-465,共2页
Journal of Clinical Neurology
关键词
原发性中枢神经系统血管炎
病理学
primary angiitis of the central nervous system
pathology
