摘要
成年哺乳动物的神经发生现象被大量研究证实,影响和调节神经发生的因素也逐渐被揭示。小胶质细胞是中枢神经系统重要的"免疫"细胞,它对神经发生具有广泛的调节作用。一方面,小胶质细胞通过与T细胞作用,或者释放神经生长因子促进神经发生;另一方面,激活的小胶质细胞释放一些细胞因子,形成一个不利于新生神经细胞的生存环境。本文对有关小胶质细胞影响神经发生的最新研究进展进行综述,这些研究进展将为理解小胶质细胞与神经发生的关系以及探索促进神经损伤修复的措施提供重要线索。
Adult neurogenesis had been confirmed in rodents and other mammals for decades.The mechanisms underlying neurogenesis have been investigated extensively in recent years.Microglial cells,an immuno-cell in the central nervous system,have been found playing important roles in modulating the process of adult neurogenesis.The inflammatory microenvironment contributed by microglia are harmful to the survival of new born neurons.On the other hand,by interacting with T cells,microglia could act as a trophic factor for neurogenesis,most possibly by releasing growth factors.We reviewed the progress on how microglia regulating adult neurogenesis in variant pathological conditions.To understand the relationship between microglia and neurogenesis will help us to approach for promising therapeutic strategy for neuronal injury.
出处
《生理科学进展》
CAS
CSCD
北大核心
2011年第1期21-25,共5页
Progress in Physiological Sciences
基金
国家自然科学基金(30772763)
教育部留学回国人员基金
教育部创新团队发展计划项目(IRT0810)资助课题
