摘要本实验通过观察七氟醚吸入麻醉和丙泊酚静脉麻醉对患儿血流动力学及肌钙蛋白I的影响,进一步探讨七氟醚吸入麻醉应用于小儿全身麻醉的可行性和安全性,为临床麻醉用药的选择提供参考。1资料与方法1.1一般资料美国麻醉医师协会（American Society of Anesthesiologists,ASA）体格情况分级Ⅰ-Ⅱ级,
7Li F, Hayes JK, Wong KC, et al. Administration of sevoflurane and isoflurane prior to prolonged global ischemia improves heart function in isolated rat heart [J]. Acta Anaesthesiol Sin, 2000, 38 (3): 113-121.
8Zaugg M, Lucchinetti E, Spahn DR, et al. Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial KATP channels via multiple signaling pathways [J]. Anesthesiology, 2002, 97 (1): 4-14.
9Wang Y, Hirai K, Ashraf M. Activation of mitochondrial ATP- sensitive K ( + ) channel for cardiac protection against ischemic injury is dependent on protein kinase C activity [ J]. Circ Res,1999, 85 (8): 731-741.
10Marinovic J, Basnjak ZJ, Stadnicka A. Preconditioning by isoflurane induces lasting sensitization of the cardiac sarcolemmaladenosine triphosphate - sensitive potassium channel by a protein kinase C-δ-mediated mechanism [J]. Anesthesiology, 2005, 103 (3): 540 - 547.
5Clifford L Coon, Robert L Simon. Method of synthesizing fluorom ethyl- hexaftuoroisopropyl ether [ P 1- US 4,250,334,19814)2-10.
6Murry CE, Jennings RB, Reimer KA. Preconditioning with isechemia:a de- lay of lethal cell injury in ischemic myocardium [ J ]. Circulation, 1986, 74 (5) :1124-1136.
7Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic post conditioning during reperfusion:comparison with ischemic pre- conditioning[J]. Am. J. Physiol. Heart Circ. Physio., 2003, 285(2):579-588.
8Singh P, Chauhan S, Jain G, et al. Comparison of Cardioprotective Effects of Volatile Anesthetics in Children Undergoing Ventricular Septal Defect Clo- sure [ J]. World Journal for Pediatric and Congenital Heart Surgery, 2013, 4 ( 1 ) :24-29.
9Knapp J, Bergmann G, Bruckner T, et al. Pre-and postconditioning effect of Sevoflurane on myocardial dysfunction after cardiopulmonary resuscitation in rats [J]. Resuscitation, 2013, 84(10) :1450-1455.
10Salic K,Padding FC. Cardioprotection via activation of protein kinase C-del- ta depends on modulation of the reverse mode of the Na +/Ca2 + exchanger [ J]. Circulation,2006,1 14( 1 Supply) : 1226-1232.
