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有机铵盐促进Gewald反应合成多取代2-氨基噻吩类化合物的研究 被引量：7

Aminium Salt Promoted Gewald Reaction to the Substituted 2-Amino-Thiophene Compounds
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摘要 2-氨基-4,5-二甲基噻吩-3-乙酸乙酯类化合物是合成小麦全蚀病的高效防治药剂硅噻菌胺的重要关键中间体.为了高效合成这类关键中间体,发展了一种新型的合成方法,利用仲胺与对甲苯磺酸复合形成有机铵盐可以高选择性地促进Gewald反应合成相应2-氨基-4,5-二甲基噻吩-3-乙酸乙酯类杂环化合物,得到较为理想的分离产率和纯度,并深入考察了在该反应中各种不同因素的影响. 2-Amino-4,5-dimethyl thiophene-3-acetic ester is an important intermediate for Silthiofam,which is highly efficient pharmacy for wheat disease.This manuscript developed a novel synthetic process for the preparation of 2-amino-thiophene derivatives through aminium salt-promoted Gewald reaction.The desired products,substituted 2-amino-thiophene derivatives,have excellent chemoselectivity and high yields under mild conditions.
作者 李莉 顾峰雷 诸坤 邱化玉
机构地区 杭州师范大学材料与化学化工学院
出处 《杭州师范大学学报（自然科学版）》 CAS 2011年第1期52-55,76,共5页 Journal of Hangzhou Normal University(Natural Science Edition)
基金 浙江省教育厅课题项目(Y200803721)
关键词 硅噻菌胺 2-氨基-4 5-二甲基噻吩-3-乙酸乙酯类化合物 Gewald反应 有机铵盐 Silthiopham 2-amino-4,5 dimethyl thiophene 3 acetic esters Gewald reaction aminium salt
分类号 O626.5 [理学—有机化学]
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参考文献14

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共引文献2

同被引文献79

  • 1胡扬根,吕茂云,宋鹤丽,丁明武.2-氨基噻吩并[2,3-d]嘧啶-4(3H)-酮衍生物的合成[J].有机化学,2005,25(3):295-298. 被引量：30
  • 2王保通,商鸿生,李强,王芳,李高宝.硅噻菌胺拌种防治小麦全蚀病试验研究[J].西北农业学报,2005,14(3):26-28. 被引量：10
  • 3薛伟,宋宝安,汪华,何伟,杨松,金林红,胡德禹,刘刚,卢平.2-[5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑-2-基硫代]-1-(2,3,4-三甲氧基)苯乙酮肟醚合成与抗烟草花叶病毒活性研究[J].有机化学,2006,26(5):702-706. 被引量：15
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引证文献7

二级引证文献26

杭州师范大学学报（自然科学版）
2011年 第1期

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