摘要
目的 研究红细胞和组织中胰岛素受体变化的相关性。方法 通过静脉注射链脲佐菌素（ Ｓｔｒｅｐｔｏｚｏｃｉｎ ， Ｓ Ｔ Ｚ） 致大鼠糖尿病模型，采用放射性配体结合法观察８ ｗｋ 内胰岛素受体变化。结果 红细胞和组织胰岛素受体各常数具有较好的相关性（ Ｐ＜ ００５） ，红细胞受体和肝细胞受体的相关性略优于肌细胞。结论 在 Ｓ Ｔ Ｚ 所致糖尿病大鼠中，红细胞膜上胰岛素受体的变化同步反映了靶细胞（ 肝和肌肉）
AIM To study the relation between INSR in erythrocytes and in target tissues. METHODS A diabetes model was induced by injection of streptozocin (iv 50 mg·kg -1 ) in rats, and the INSR constants in erythrocytes, liver and skeleton muscle were determined with radioreceptor assay within 8 weeks. RESULTS INSR in erythrocytes and in target tissues were correlated ( r >0 805, P <0 05), and the correlativity of INSR between erythrocytes and liver ( r >0 934, P <0 01) was better than that between erythrocytes and skeleton muscle. CONCLUSION The INSR alteration in erythrocytes of ST 2 rats synchronously reflected the change in target tissues(liver and skeleton muscle), which gave us a new clinical possibility to monitor the proceeding degree of diabetes mellilus. KEY WORD Insulin receptor; radioreceptor assay; erythrocyte; liver; skeleton muscle
出处
《中国药理学通报》
CAS
CSCD
北大核心
1999年第4期319-321,共3页
Chinese Pharmacological Bulletin
基金
全军医药卫生科研基金
