摘要
目的 研究箬叶多糖及其衍生物硫酸酯多糖和硒酸酯多糖对小鼠艾滋病的治疗作用。方法 采用 Ｌ Ｐ Ｂ Ｍ５ 鼠白血病病毒（ Ｍｕ Ｌ Ｖ） 感染 Ｃ５７ Ｂ Ｌ／６ Ｊ 小鼠的方法建立艾滋病模型。结果 硫酸酯多糖５０ ｍｇ·ｋｇ － １·ｄ － １（ｉｐ） 具有较好地抑制小鼠脾肿大、血清 Ｉｇ Ｇ 增高的作用，硒酸酯多糖在两种给药方式中有一定的保护作用。此外，还首次发现感染小鼠出现 Ｇ Ｓ Ｈ Ｐｘ 活力下降，脂质过氧化产物升高，这与 Ｈ Ｉ Ｖ感染的病人的症状是一致的，硒多糖对提高机体的抗氧化功能有较好的作用。多糖经硫酸酯化、硒酸酯化等化学修饰后，活性有不同程度的提高。结论 作为抗氧化剂和免疫增强剂的微量元素硒和多糖类可能对 Ｈ Ｉ Ｖ
AIM To report antiretrovial activities of polysaccharide(PS) isolated from Chinese traditional medicine Ruoye (Indocalamus tesselatus) grown in Enshi, Hubei and its derivative selenopolysaccharide (Se PS) and sulfated polysaccharide (S PS). Effect of these compounds on the development of murine AIDS (MAIDS) caused by the LP BM5 murine leukemia virus (MuLV) was studied. METHOD C57BL/6J female mice were inoculated intraperitoneally (ip) with LP BM5 murine virus and treated with drugs (ip or ig) every day. RESULTS S PS 50 mg·kg -1 per day (ip) inhibited splenomegaly and serum IgG elevation, in agreement with AZT(10 mg·kg -1 ·d -1 ,ig) 4 weeks later. In addition, Se PS and S PS could increase blood GSH Px activity significantly, and only Se PS decreased lipid peroxidative product of spleen effectively. CONCLUSION Antioxidant molecules may be of therapeutic value in the treatment of HIV infected patients.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1999年第4期336-340,共5页
Chinese Pharmacological Bulletin
关键词
箬叶多糖
硫酸酯多糖
艾滋病
免疫增强剂
Indocalamus tesselatus polysaccharide
polysaccharide sulfate
polysaccharide selenate
AIDS
antioxidant
