摘要
目的研究肠内营养对获得性免疫缺陷综合征（AIDS）患者T淋巴细胞免疫功能的影响。方法采用随机数字法将79例AIDS患者随机分为两组：（1）对照组（n=33）：仅给予常规治疗；（2）肠内营养（EN）组（n=46）：在常规治疗的基础上，每日给予EN。于试验前和试验第30天，分别测定两组患者的CD3、CD4、CD8细胞计数。结果试验前，两组患者的血糖及血丙氨酸转氨酶、天冬氨酸转氨酶、总蛋白（TP）、白蛋白（ALB）和尿素氮、肌酐、前白蛋白（PA）水平间差异均无统计学意义（P均〉0．05）；试验第30天，EN组患者的血TP（P=0．015）、ALB（P=0．007）和PA（P=0．022）水平明显高于对照组。对照组试验前与试验第30天的CD3、CD4、CD8细胞计数问差异均无统计学意义（P均〉0．05），EN组患者试验第30天的CD4细胞计数明显高于试验前（P=0．012）。结论EN支持可改善AIDS患者的营养状况和T淋巴细胞免疫功能。
Objective To investigate the effect of enteral nutrition （EN） on the T lymphocytes-mediated immune function in patients with acquired immune deficiency syndrome （AIDS）. Methods Totally 79 AIDS patients were randomly divided into enteral nutrition （EN） group （supported with EN daily in addition to conventional treatment; n = 46） and control group （underwent conventional treatment only; n = 33 ）. T lymphocytes including CD3, CIM, and CD8 cells as well as blood biochemical parameters including alanine aminotransferase （ ALT）, aspartate aminotransferase （AST）, glucose （ Glu ）, total protein （ TP）, albumin （ ALB ）, blood urea nitrogen （BUN）, Cr, and prealbumin （PA） were determined immediately before management （To） and on the 30＇s day （T1 ）. Results ALT, AST, Glu, TP, ALB, BUN, Cr, and PA showed no significant differences between these two groups before management （ all P 〉 0.05 ）. The levels of TP （ P = 0. 015 ）, ALB （ P = 0. 007 ）, and PA （ P = 0. 022 ） were significantly higher in EN group than those in control group at T1. The cell counts of CD3, CDd, and CD8 wcrc not significantly different at To, while the cell count of CIM was significantly higher in EN group than that in control group at T1 （P 〈 0. 05 ）. Conclusion EN can improve the nutritional status and T lymphocytesmediated immune function in AIDS patients.
出处
《中华临床营养杂志》
CAS
2011年第1期12-15,共4页
Chinese Journal of Clinical Nutrition
基金
昆明市科技计划项目（昆科计字05S603034）
