摘要
目的:探讨血清可溶性细胞表面分化抗原CD40配体(sCD40L)、脂联素水平与2型糖尿病并发急性冠脉综合征的关系及其临床意义。方法:采用ELISA检测62例2型糖尿病并发急性冠脉综合征患者、61例无并发症的2型糖尿病患者血清sCD40L和脂联素浓度,并以60例健康人作为对照。结果:2型糖尿病并发ACS组的血清sCD40L和FPG水平高于无并发症组及正常对照组(均P<0.01),而APN水平则显著降低;(P<0.01);DM并发ACS组血清sCD40L水平较DM无并发症组也显著升高(P<0.01),APN水平也显著降低(P<0.01);DM并发UA组血清sCD40L水平较DM并发AMI组升高(P<0.05),而血清adiponectin水平降低(P<0.05);血清sCD40L与APN水平呈显著负相关(r=-0.765,P<0.01),血清FPG与sCD40L、APN水平无相关关系(r=0.076,r=-0.116,均P>0.05)。结论:血清sCD40L、APN可能参与了2型糖尿病并发ACS的发病过程,可能成为ACS并发症的预测因子。
Objective：To explore the relation between serum sCD40L、adiponectin level and type2 diabetic acute coronary Syndrome complication and its clinical significance.Methods： Serum levels of sCD40L and adiponectin were measured with ELISA in 62 cases of type 2 diabetic patients with ACS complications,61 cases of the absence of no complications in patients with type 2 diabetes and 60 healthy subjects as controls.Results： The levels of serum sCD40L and FPG in type 2 diabetic patients with ACS group and no complications group were higher than that of control group respectively（all P0.01）,while the adiponectin was significantly lower.The levels of serum sCD40L in type 2 diabetic patients with ACS group was higher than that of in no complications group,and the adiponectin was also lower.The levels of serum sCD40L in type 2 diabetic patients with UA group was higher than that of in type 2 diabetic patients with AMI group,while the adiponectin was converse.The serum level of sCD40L is significantly negative correlation with adiponectin（r=-0.765,P0.01）,and there were no correlation between the serum level of FPG and sCD40L,adiponectin（r=0.076,r=-0.116,all P0.05）.Conclusion： Serum sCD40L and adiponectin may be involved in the pathogenesis of 2 diabetic patients with ACS,which may be a predictor of 2 diabetic patients with ACS complications.
出处
《中国卫生检验杂志》
CAS
2011年第1期161-163,共3页
Chinese Journal of Health Laboratory Technology
