摘要
目的:探讨MMP-2在不同类型退变腰椎间盘组织中的表达。方法:用免疫组化方法检测56个退变腰椎间盘组织与10个正常腰椎间盘组织中MMP-2的表达。结果:退变腰椎间盘组织中MMP-2阳性细胞率为(58.45±20.37)%,高于正常椎间盘组织的(3.54±0.96)%(t=8.960,P<0.001)。突出型、破裂型及游离型退变腰椎间盘组织中MMP-2阳性细胞率分别为(33.17±8.48)%、(69.32±5.91)%和(75.67±6.00)%,差异有统计学意义(F=208.558,P<0.001);破裂型较突出型椎间盘组织中MMP-2表达增高(P<0.001),游离型较突出型以及破裂型椎间盘组织中MMP-2表达增高(P<0.05)。结论:MMP-2高表达可能与腰椎间盘退变有关。
Aim：To study the expression of matrix metalloproteinase-2（MMP-2）in degenerated lumbar intervertebral disc tissue.Methods：A total of 56 specimens of degenerated lumbar intervertebral disc and 10 specimens of normal lumbar intervertebral disc were subjected to detect the expression of MMP-2 using immunohistochemistry methods.Results：The expression of MMP-2 in degenerated lumbar intervertebral disc was higher than that in the normal intervertebral disc tissue [（58.45±20.37）% vs（3.54±0.96）%,t=8.960,P〈0.001].There were significant differences among the MMP-2 expressions in sequested disc,ruptured disc and prominent disc tissues [（75.67±6.00）%,（69.32±5.91）%,and（33.17±8.48）%,F=208.558,P〈0.001].The expression of MMP-2 decreased by turn from sequested disc,ruptured disc to prominent disc（P〈0.05）.Conclusion：MMP-2 may be related to lumbar intervertebral disc degeneration.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2011年第1期85-88,共4页
Journal of Zhengzhou University(Medical Sciences)
关键词
腰椎间盘
基质金属蛋白酶-2
退变
lumbar intervertebral disc
matrix metalloproteinase-2
degeneration
