摘要
目的:探讨支气管哮喘发病中肺表面活性蛋白A(SP-A),肿瘤坏死因(TNF-α),白介素6(IL-6),白介素8(IL-8)结果的变化及其分析研究。方法:测定102位支气管哮喘患者急性发作期和缓解期的SP-A、TNF-α、IL-6、IL-8及同期健康对照75人。结果:急性发作期的SP-A显著低于缓解期(P<0.05),急性发作期的TNF-α、IL-6、IL-8显著高于缓解期(P<0.05),急性发作期的TNF-α、IL-6、IL-8显著高于健康对照。结论:支气管哮喘的发作虽然是多种病因引起,TNF-α、IL-6、IL-8等一些细胞因子在中有重要的作用。证明SP-A对细胞因子的调节作用是多方面的,表现为对免疫调节的双向性及复杂性。
Objective：To investigate the pathogenesis of bronchial asthma,pulmonary surfactant protein A（SP-A）,tumor necrosis factor（TNF-α）,interleukin 6（IL-6）,interleukin-8（IL-8） results Changes and analysis.Methods： 102 patients with acute asthma exacerbation and remission of SP-A,TNF-α,IL-6,IL-8,and 75 healthy controls over the same period.Results： Acute exacerbation of SP-A was significantly lower than in remission（P0.05）,acute exacerbation of TNF-α,IL-6,IL-8 was significantly higher than in remission（P0.05）,acute exac-erbation of TNF-α,IL-6,IL-8 was significantly higher than healthy controls.Conclusion： Although the onset of bronchial asthma caused by a variety of causes,TNF-α,IL-6,IL-8 and some other cytokines have an important r-ole.Prove that SP-A on cytokine regulation of many aspects,the performance of two-way for the immune regul-ation,complexity.
出处
《中国卫生检验杂志》
CAS
2011年第2期450-451,453,共3页
Chinese Journal of Health Laboratory Technology
