摘要
目的：通过动物实验验证ｂＦＧＦ 有促进骨折愈合的作用，并探索ｂＦＧＦ 临床应用效果。方法：对２０ 只兔手术造成桡骨骨折。局部注射ｂＦＧＦ，通过肉眼观察、Ｘ 线片，测量骨折、测定骨折愈合处骨密度、测定骨折愈合后的抗折力及病理学切片检查来观察骨折愈合情况。将应用于临床１１ 例骨折病人，骨延长、骨髓炎各２ 例，随访６ ～２４ 月。结果：注射ｂＦＧＦ 侧骨痂生长多而迅速，骨愈合处骨密度比对照组显著增高，抗折力比对照侧明显强。病理学切片显示注射ｂＦＧＦ 侧成纤维细胞多、骨痂多、成骨细胞多，骨小梁、骨基质形成快，骨折愈合快。临床１５ 例患者应用ｂＦＧＦ 后都有明显的促进骨折愈合，促进骨质生长、创口愈合的作用。结论：ｂＦＧＦ 有促进骨质愈合的作用。
Objective :bFGF has the effect of prom oting the fracture healing w hich is verified by animal experim ent and pu vpose of this study is to explore the clinical effects of appling bFGF.Methods :Twenty rabbits were caused fracture of radius on both sides .bFGF was injected into the fissure .Observe the fracture healing state with naked eyes ,X ray ,histopathological sec tion and measuring the bone density and antibending force after healing .bFGF was applied to 15 clinical patients to do som e re search .11 of the 15 patients were fractures ,2 were prolongation oflim bs ,2 were osteom yelitis .They were follo wed up for 6 ～24 m onths .Results :It was found that on the injecting bFGFside the callus was growing more quickly and vigorously ,the bone den sity was higher and the antibending force was stronger .Histopathological section also showed on that side there were m ore fi broblasts ,osteoblasts and callus ,the trabeculae and basic tissue were growing faster ,the fracture was healing m ore quickly .Fif teen patients are confirmed that bFGF has the effect of pro moting the fracture healing ,facilitating the bone growth and the wound healing .Conclusion :bFGF has the effect of prom oting the fracture healing .
出处
《中国矫形外科杂志》
CAS
CSCD
1999年第11期838-840,共3页
Orthopedic Journal of China
关键词
BFGF
骨折愈合
实验
临床应用
bFGF(basic fibroblast gro wing factor) Fracture healing
