血浆TNF-α，sICAM-1水平与CHF患者病变进展关系的研究被引量：3

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摘要目的观察充血性心力衰竭（CHF）患者血浆肿瘤坏死因子（TNF-α）、可溶性细胞黏附分子（siCAM-1）水平的变化规律。方法采用酶联免疫吸附法分别检测50例CHF患者血浆TNF-α和siCAM-1水平，并与临床资料进行对比分析。结果TNF-α上升幅度与患者冠状动脉病变程度（r=0．5501，P〈0．01），E／A比值（r=0．6237，P〈0．01）和射血分数（r=0．8564，P〈0．01）之间存在相关；sICAM-1水平升高幅度与冠状动脉病变程度（r=0．6359，P〈O．0I），左室射血分数（r=0．8751，P〈O．01）和血脂水平（r=0．5342，P〈0．01）之间存在相关；TNF-α和sICAM=1之间存在正相关（r=0．4702，P〈0．01）。结论CHF患者血浆TNF-α和sicAM-1高水平表达预示病情进展。

作者付卫国冯娜张凡常永霞杨宝友冯晓云

机构地区玉田县医院检验科河间县医院检验科河北北方学院附属第一医院病理科

出处《现代检验医学杂志》 CAS 2011年第1期112-114,共3页 Journal of Modern Laboratory Medicine

关键词充血性心力衰竭肿瘤坏死因子(TNF-α) 可溶性细胞黏附分子(sICAM一1) 炎症性细胞因子预后

分类号 R541.61 [医药卫生—心血管疾病] R392.11 [医药卫生—免疫学]

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1Wand O,Perles Z,Rein AJ ,et al. Clinical ,echocardio- graphic and humoral status of patients following re- pair of tetralogy of Fallot:comparison of the second to the first decade[J]. 1st Med Assoc 0r,2007,9(12): 843-846.
2Ben Driss A,Tabet JY,Meurin P,et al. BNP and e- chocardiography can predict the occurrence of acute cardiac decompensation during titration of bisoprolol in chronic systolic heart failure[J]. Arch Mal Coeur Vaiss, 2007,100(11) : 934-940.
3Bertinchant JP,Ledermann B, Schmutz L,et al. Diag- nostic and prognostic significance of CK-MB, Tro- ponins, CRP, BNP and/or NT-proBNP in coronary angioplasty. Elevation mechanisms, clinical implica- tions [J]. Arch Mal Coeur Vaiss, 2007,100 (11) : 925- 933.
4Bell D,Zhao YY,Devine AB,et al. Influence of Ate- nolol and Nifedipine on Nitric-Oxide Deficient Car- diomyocyte Hypertrophy and Expression of the Car- clio-Endocrine Peptide Intermedin and its Receptor Components [J]. Cell Physiol Biochem, 2008, 21 (1- 3) : 203-214.
5Torres Pérez I, del Rio Sdnehez C, Borda Mas M. MCMI-II borderline personality disorder in anorexia and bulimia nervosa [J]. Psicothema, 2008, 20 (1): 138-143.
6Woodard GE,Rosado JA. Recent advances in natri- uretie peptide research[J]. J Cell MolMed,2007,11 (6):1263-1271.
7Kānig D, Neubauer O, Nics L, et al. Biomarkers of exercise-induced myocardial stress in relation to in- flammatory and oxidative stress[J]. Exerc Immunol, 2007,13:15-36.
8Chandra A,Otero R,Freeman D,et al. BNP-Mediat- ed Vasodilatation for Dialysis-Dependent Patient with Acute Heart Failure Syndrome in the Emergen- cy Department [J]. Ren Fail, 2008,30 (1) : 45-50.
9Childakis JA,Koutsogiannis N,Kalogeropoulos A,et al. Unfavourable effects of continuous, atrial-syn- chronised ventricular pacing on ventricular systolic and diastolic function in patients with normal left ventricular ejection fraction:usefulness of tissue and colour Doppler echocardiography[J]. Hellenic J Car- diol,2007,48(6) :335-340.