摘要
目的寻找复发难治性前体淋巴细胞白血病／淋巴瘤诱导缓解的有效方法。方法以CAG预激方案联合左旋门冬酰胺酶（L-Asp）和泼尼松（PDN）诱导治疗6例复发难治性前体淋巴细胞白血病／淋巴瘤和1例急性杂合细胞白血病。结果6例患者完全缓解（CR），1例部分缓解（PR），总有效率100％（7／7），cR率85．7％（6／7）。患者不良反应轻，均可耐受。结论CAG联合L-Asp和PDN是复发难治性前体淋巴细胞白血病／淋巴瘤值得尝试的诱导化疗方案。
Objective To explore the effective treatment with regimen of remission induction for relapsed/refractory precursor lymphocytic leukemia/lymphoma patients. Methods 6 patients with relapsed/ refractory precursor lymphocytic leukemia/lymphoma including 2 acute lymphocytic leukemia, 4 lymphob]ast lymphoma and 1 hybrid acute leukemia were treated by combination of CAG regimen with L-asparaginase （L-Asp） and prednisone （PDN）. Results All patients responded to the regimen, in which 6/7 （85.7 %） patients achieved complete remission and 1/7 （14.3 %） patient achieved partial remission after one course. Light adverse events coursed by the regimen could be tolerated. Conclusion The regimen consisting of CAG, PDN and L-Asp is worth exploring for relapsed/refractory precursor lymphocytic leukemia/ lymphoma.
出处
《白血病．淋巴瘤》
CAS
2011年第2期89-91,共3页
Journal of Leukemia & Lymphoma
