摘要
目的探讨丙泊酚联合瑞芬太尼不同配比用于静脉全身麻醉的效果。方法将63例患者随机分为三组，每组21例，各组的丙泊酚与瑞芬太尼血浆靶浓度不同。记录不同时刻血流动力学指标平均动脉压（MAP）、心率（HR）的变化情况，以停麻药的时间为零点计时，记录苏醒时间和拔管时间以及苏醒情况，并进行比较。结果三组患者插管前的MAP和HR值，较麻醉诱导前均明显降低（均P〈0．05）。插管后即刻、拔管时与插管前差异均有统计学意义（均P〈0．05）。拔管后5min的MAP和HR与麻醉诱导前差异均无统计学意义（均P〉0．05）。A组的苏醒时间、拔管时间最短，术后苏醒质量评分最佳。B组次之。C组的苏醒时间、拔管时间最长、苏醒质量最差。三组之间的差异均有统计学意义（均P〈0．05）。结论丙泊酚复合瑞芬太尼血浆浓度2．5mg／L与8μg/L时麻醉效果最好，随丙泊酚浓度降低及瑞芬太尼浓度增加，患者苏醒时间、拔管时间逐渐缩短，苏醒质量逐渐提高。
Objective To explore the effects of propofol combined with remifentanil in different ratios for intravenous anesthesia. Methods 63 patients were randomly divided into three groups, each group 21 cases, different target plasma concentration of propofol and remifentanil were dosed for every group. Hemodynamic parameters such as MAP,HR were recorded at different time. so as to stop time for the zero time of local anesthetic. The extubation time, the quality and time of awakening were compared as well. Results The MAP and HR value of all patients after in- duction of general anesthesia were lower than that before intubation, which showed significant difference （ all P 〈 0.05）, and the MAP and HR value of all patients after intubation reseal and deeannulation showed significant difference compared with that before intubation reseal. The resurgence time and decannulation time of group A were the shortest,and the postoperative detubation revive quality score was also the best when compared with that of group B and C. Conclusion The target plasma concentration of propofol（2.5mg/L） and remifentanil（μg/L） was the best. With the increasing of target plasma concentration of remifentanil and the decreasing of target plasma concentration of propofol, the resurgence time, decannulation time and the postoperative detubation revive quality score were improved gradually.
出处
《中国基层医药》
CAS
2011年第4期500-502,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
丙泊酚
瑞芬太尼
全身麻醉
Propofol
Remifentanil
General anesthesia
