摘要
目的优选薄荷油β-环糊精聚合物(β-CDP)微球包合的最佳工艺。方法采用饱和水溶液法制备薄荷油β-CDP微球包合物,通过L9(34)正交试验设计以回归分析法为指标对制备工艺进行了优化;分别用红外光谱、综合热分析和X射线衍射分析法对薄荷油β-CDP微球包合物进行表征。结果最佳制备工艺条件是选定A2B2C1D3;影响因素的大小依次为:β-CDP微球和与水之比>β-CDP微球和薄荷挥发油投料比>包合温度>包合时间;IR、XRD、TGA等方法证明了包合物的生成。结论薄荷油的包合方法合理可行。
Objective To optimize the including preparation for peppermint oil-β-cyclodextrin polymer（β-CDP） microsphere inclusion compound.Methods Peppermint oil-β-CDP microsphere inclusion compound was prepared by using co-precipitation.The preparation process was optimized through the L9（34） orthogonal test design and regression analysis.Peppermint oil-β-CDP microsphere inclusion compound was characterized by infrared（IR） spectroscopy,thermogravimetric analysis（TGA）,and X-ray diffraction（XRD）.Results The best technological condition was A2B2C1D3,and the order of the influence factors was the proportion of β-CDP microsphere and water the percentage of peppermint oil in β-CDP microsphere inclusion temperature inclusion time.The formation of peppermint oil β-CDP microspheres inclusion compound was proved by the results of IR,XRD,TGA analyses.Conclusion The method is reasonable and feasible.
出处
《中草药》
CAS
CSCD
北大核心
2011年第2期271-274,共4页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(50573046)
陕西科技大学研究生创新基金资助
关键词
薄荷油
β-环糊精聚合物微球
红外光谱
X衍射
热重分析
peppermint oil
β-cyclodextrin polymer（β-CDP） microsphere
infrared（IR） spectroscopy
X-ray diffraction（XRD）
thermogravimetric analysis（TGA）
