摘要
目的通过近年来本院分离培养鉴定的大肠埃希菌对多种抗生素的耐药状况的分析及产ESBLs酶的检出情况。为临床合理使用抗生素提供依据。方法收集奉天医院2005年1月～2009年12月间各种临床标本中分离的大肠埃希菌731株,应用DL-96E细菌鉴定系统进行鉴定,药敏实验用K-B纸片法,同时运用CLSI推荐方法检测ESBLs酶。结果大肠埃希菌对亚胺培南、美罗培南、阿米卡星、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、头孢西丁、氨曲南、头孢吡肟、头孢他啶耐药性较低,在0.10%～28.45%,其他抗菌药物都产生较高的耐药性,差异有统计学意义。结论临床大肠埃希菌耐药率逐渐增强,与临床不合理使用抗生素有一定关系。产ESBLs酶大肠埃希菌的检出应引起临床高度重视。
Objective Investigate the antibiotic resistance of Escherichia（E.coli） and the detection of ESBLs-producing in the fengtian hospital of Shenyang medical college,provide the redible antimicrobial susceptibility test（ATB） results for clinial antibiotic use.Methods We collected 731 clinical strains of E.coli from different types of clinical samples from Jan.2005 to Dec.2009,and identified them with DL-96E system.K-B methods were used in ATB.ESBLs was examined with the method recommended by CLSI.Results E.coli was sensitive to IPM,MER,AK,CFS,TZP,FOX,FEP,CAZ,and the antibiotic resistance was 0.10%～28.45%.E.coli was resistant to the other drugs.Conclusion The rate of antibiotic resistang of E.coli was increased.We must pay more attention to ESBLs-producing E.coli.
出处
《当代医学》
2011年第7期42-43,137,共3页
Contemporary Medicine
