摘要
目的通过对比支气管哮喘(哮喘)患儿规范化治疗前后肺功能指标的变化,探讨其大小呼吸道功能改变及改变时间段。通过对比哮喘患儿吸入支气管扩张剂前后肺功能变化,明确哮喘患儿对支气管扩张剂的反应及呼吸道狭窄、呼吸道阻塞的可逆性。方法采用肺功能测定系统对25例哮喘患儿分别于哮喘急性发作期、正规治疗后缓解期3个月、6个月、1 a行常规肺通气功能测定,比较各期实测值与预测值;并从中选出10例患儿于急性发作期行支气管舒张试验,比较支气管扩张剂雾化吸入前后其肺功能指标变化。结果哮喘患儿急性发作期用力肺活量(FVC)、一秒钟用力呼气量(FEV1)、1秒率(FEV 1.0%)、最大呼气流量(PEF)、25%用力呼气肺活量(FEF25)、FEF50、FEF75、中段呼气流速(MMEF75/25)等实测值均较预测值降低,治疗3个月FVC、FEV1等大呼吸道功能指标恢复,治疗1 a、FEF50、FEF75、MMEF75/25等小呼吸道功能指标恢复。哮喘患儿支气管扩张剂雾化吸入后大呼吸道功能指标FEV1、PEF及小呼吸道功能指标FEF50、FEF75、MMEF75/25等均较雾化前恢复。结论哮喘患儿的肺功能指标在急性期和缓解期存在特异性动态变化,肺功能检测在儿童哮喘的诊断、疗效及病情判断方面具有良好的作用。
Objective To investigate the changes in the large and small airway function in children with asthma and the time interval changes by comparing the lung function indexes pre and post regular treatment.To reveal the response of airway to bronchodilator and the reversibility of airway stenosis and obstruction in children with asthma in different ages by comparing the changes of lung function of asthmatic children pre and post inhaled bronchodilator.Methods Twenty-five children with asthma were measured with general pulmonary at acute stage,remission stage of 3 months,6 months and 1 year,the measured value and the estimated value of different stage were compared.Moreover,10 cases of them were received bronchodilation test respectively among acute attack period.Results The measured value of forced vital capacity（FVC）,forced expiratory volume in one second（FEV1）,forced expiratory volume in one second to forced vital capacity ratio（FEV 1.0%）,peak expiratory flow（PEF）,forced expiratory flow after 25%,50%,75%（FEF25,FEF50,FEF75）,maximal midexpiratory flow（MMEF75/25）were lower than predicted value in acute stage,then recovered in remission stage,the large airway function index were recovered after 3 months′ therapy,and after treatment of 1 year or more,the small airway function were recoveried.Indicators of large airway function such as FEV1 and PEF,and indicators of small airway function of FEF50,FEF75,MMEF75/25 etc.were recorded after atomized.Conclusions There are dynamical changes of the lung function index during acute and remission stage,so pulmonary function testing has a good assessment in diagnosis,efficacy and disease in children with asthma.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2011年第4期257-259,共3页
Journal of Applied Clinical Pediatrics
基金
河北省医学适用技术跟踪项目(GL200841)
