摘要
目的研究新生儿重症监护病房(NICU)医院感染败血症的病原学变化、临床特点及相关的影响因素,为医院感染病例监测和及时诊断提供依据。方法 2006年1月-2009年12月,新生儿重症监护病房共监测并确诊医院感染败血症54例,按病原分为革兰阳性球菌感染组25例,革兰阴性杆菌感染组16例,真菌感染组13例,对各组相关的影响因素及临床特点进行分析研究。结果病原菌分布构成比中革兰阳性球菌最高占46.30%,革兰阴性杆菌占29.63%,真菌占24.07%;低体重、早产儿、使用医疗技术操作和多种抗菌药物时间较长、住院时间较长等均能增加医院感染败血症的危险性;临床表现同一般的感染症状,无特殊性。结论 NICU对存在有以上危险因素的新生儿出现感染症状,医院感染管理科专职人员应加强监测,尽早诊断医院感染败血症病例;早发现、早诊断和采取积极的治疗措施是影响预后的重要因素。
OBJECTIVE To study the changes in sepsis etiology, clinical features and the related risk factors of septicemia, to provide bases for hospital infection surveillance and timely diagnosis. METHODS Totally 54 cases of nosocomlal septicemia were monitored and diagnosed in NICU in the four years from Jan 2006 to Dec 2009,and were divided into G＋ cocci infection group with 25 cases, G- bacillus infection group with 16 cases and fungal infection group with 13 cases. The impact factors and clinical characteristics of the three groups were analyzed. RESULTS G＋ cocci proportion was in declining with 46.30%, G- bacilli increased with each year 29. 63%, the proportion of fungi also could not be ignored with 24.07%. It increased the risk of nosocomial septicemia in the cases of low birth weight, premature children, the use of medical technical operations, various antibiotics for a longer time, longer hospital stay and so on. The longer the stay in hospital was, the more likely the infection of G- bacilli and fungi acquired. Clinical features were the same as general infection symptoms, with no particularity. CONCLUSION It is important to early diagnose the septicemia cases of hospital infection for NICU. Monitoring to infectious symptom of the newborns should be strengthened to diagnose the septicemia in early state, earlier detection and diagnosis and effective treatment measures are important factors to influence the prognosis.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第5期888-890,共3页
Chinese Journal of Nosocomiology
