摘要
目的研究患者行开颅术后继发肺部感染的病原菌及其耐药性,为临床治疗提供依据。方法对医院神经外科2008年1月-2009年10月开颅术后继发肺部感染患者的病原菌分布及耐药性进行回顾性分析。结果颅脑手术后继发肺部感染送检标本培养出病原菌182株,其中革兰阴性菌121株,占66.5%,革兰阳性菌25株,占13.7%,真菌36株,占19.8%;感染率最高的病原菌是鲍氏不动杆菌(27.5%)和白色假丝酵母菌(14.3%);所选的抗菌药物中,对革兰阴性菌敏感性较高的有哌拉西林/他唑巴坦、亚胺培南、头孢哌酮/舒巴坦,对革兰阳性菌敏感性较高的药物有万古霉素、利福平。结论鲍氏不动杆菌、白色假丝酵母菌是医院开颅术后继发肺部感染时最常见的病原菌,且细菌耐药严重;因此,应加强痰培养细菌检测,以便识别病原菌,选择敏感药物及减少耐药菌的产生。
OBJECTIVE To study the pathogens causing secondary pulmonary infection in post-craniotomy patients, and so as to provide reference for clinical therapy. METHODS The pathogen category and drug resistance were analyzed in post-craniotomy patients with secondary pulmonary infection from Jan 2008 and Oct 2009. RESULTS A total of 182 strains of pathogens were isolated, of which G bacteria accounted for 121 strains （66.5%）, G＋ bacteria 23 strains （12. 6%）, fungi 36 strains （19. 8%）. The pathogens with the highest infection rates were Acinetobacter baumannii （27.5% ） and Candida albicans （ 14.3%） . The resules of drug sensitivity test were that： the sensitive drugs for G-bacteria were in piperacillin/tazobatam, imipenem, cefoperazone/sulbactam respectively; the sensitive drugs for G＋ bacteria were vancomycin, and rifampiein respectively. CONCLUSION A. baumannii and C. albicans are the most common pathogens in post-craniotomy patients with secondary pulmonary infection in our hospital,and they have a high drug resistant rate. Thus,the detection of sputum culture should be strengthened so as to identify the pathogens, select sensitive drugs and decrease the drug resistant strains.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第5期992-995,共4页
Chinese Journal of Nosocomiology
关键词
开颅术后
肺部感染
病原菌
耐药性
Post-craniotomy
Pulmonary infection
Pathogens
Drug resistance
