摘要
目的探讨单用依沙吖啶和依沙吖啶联合米非司酮对妊娠中期,因胎儿畸形等需要终止妊娠者进行引产的效果。方法回顾性分析132例引产者单用依沙吖啶(对照组)和依沙吖啶联合米非司酮(观察组)进行引产的临床疗效及安全性。观察组(66例)使用依沙吖啶100mg羊膜腔注射,同时口服米非司酮100mg;对照组(66例)单纯羊膜腔内注射依沙吖啶100mg。观察两组羊膜腔内注药到宫缩开始时间、宫缩开始至胎儿娩出时间、产后出血量的情况。结果与对照组比较,观察组宫缩开始时间较早(29.55±7.33比38.55±11.57h,P<0.001),胎儿娩出时间明显缩短(5.07±1.36比6.81±2.88h,P<0.05),住院时间短(4.89±2.22比5.79±2.50d,P<0.05),差异有统计学意义;胎盘娩出时间(7.61±8.88比8.17±8.12,P=0.268)和产后出血量比较,差异无统计学意义(P>0.05)。结论应用依沙吖啶联合米非司酮进行引产是终止中期妊娠安全、较理想的方法。
Objective To study the effects of low dose mifepristone combined with ethacridine in induction of labor in second-trimester pregnancy.Methods The clinical effect and safety of ethacridine and mifepristone combined with ethacridine were analyzed retrospectively.One hundred and thirty-two cases with 14～27 gestational weeks desiring to be induction of labor were divided into study group and control group.66 cases in study group were injected 100 mg ethacridine into the amniotic cavity routinely and then 100 mg mifepristone was oral after the injection;66 cases in control group were injected 100 mg ethacridine into the amniotic cavity routinely.Results There was significant difference on fetal delivery time（first labor stage：29.55±7.33 vs 38.55±11.57,P0.001;second labor stage：5.07±1.36 vs 6.81±2.88,P0.05）and length of stay（4.89±2.22 vs 5.79±2.50,P0.05）in hospital between two groups.There was no significant difference in placenta delivery time（7.61±8.88 vs 8.17±8.12,P=0.2680.05）and postpartum hemorrhage（P0.05）between two groups.Conclusions It could increase the successful rate and reduce induction time of single induced labor by taken mifepristone combining with ethacridine.It was a safe,reliable and high effective induced method for selected cases properly.
出处
《中华保健医学杂志》
2011年第1期42-44,共3页
Chinese Journal of Health Care and Medicine
关键词
引产
妊娠中期
依沙吖啶
米非司酮
Medical induced labor
Second-trimester pregnancy
Mifepristone
Ethacridine
