摘要
目的评价血清层粘连蛋白(laminin,LN)对肝病患者肝纤维化程度的诊断价值。方法采用化学发光法测定92例各种病毒性肝炎患者及70名健康献血者血清LN水平,比较各组病毒性肝炎之间及健康献血者血清层粘连蛋白水平差异,结合病理结果进行统计学分析。结果血清LN水平在中度慢性肝炎患者明显升高,以肝硬化者为最高,4组患者与对照组比较,均有显著性差异(P<0.05),其升高程度与肝纤维化及肝病严重程度呈正相关,但与肝内炎症、坏死程度无明显关系。结论动态测定血清LN水平,可作为反映慢性肝病肝纤维化严重程度和预后的指标。
Objective To research for the diagnostic value of LN for hepatic fibrosis.Methods Chemi-luminescence immunoassay（CLIA） was used to measure the level of LN in serum of 92 patients with virus hepatitis and 70 healthy people.The data combined with the pathological alteration were analyzed.Results The level of LN in serum of patients with medium chronic hepatitis obviously heightened,and the LN level of hepatocirrhosis were the highest.Differences anong these 4 groups and with the control groups were significant（P0.05）.The increased degree was positively related to the degree of hepatic fibrosis and severity of liver disease,but the correlation with the degree of liver＇s inflammation and necrosis was not obvious.Conclusion Detecting the level of LN in serum dynamicly can reflect the fibrosis degree of chronic liver disease and the prognosis of patients.
出处
《实用医药杂志》
2011年第2期106-107,共2页
Practical Journal of Medicine & Pharmacy
关键词
肝病
层粘连蛋白
肝纤维化
Hepatopath
Laminin（LN）
Hepatic fibrosis
