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肿瘤细胞中血管内皮生长因子表达调控的研究进展 被引量：2

Research Advances of the Regulation of Vascular Endothelial Growth Factor Expression in Malignant Cells
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摘要 血管内皮生长因子(VEGF)是重要的促血管生成因子,可由巨噬细胞、基质细胞和视网膜内皮细胞分泌,也可由肿瘤细胞分泌,其主要功能在于促进血管内皮细胞的分裂和增长,诱导新生血管形成。VEGF过表达与多种肿瘤的进展及预后不良密切相关。近年来研究发现,缺氧、生长因子和细胞因子、癌基因和抑癌基因以及激素等因素均参与肿瘤细胞VEGF的表达调控。 Vascular endothelial growth factor（VEGF）is an important angiogenic factor,secreted by macrophages,stromal cells,endothelial cells of retina as well as malignant cells.The main function of VEGF is the powerful mitogene specific effect on endothelial cells and normal physiological and pathological growth of any type of blood vessels.Overexpression of VEGF is closely related to the progression and poor prognosis in a variety of cancers.Recent evidence suggests that hypoxia,growth factors,cytokines,oncogene and tumor suppress genes and hormones are the regulators of VEGF expression in malignant cells.
作者 弓唯一 董竞成
机构地区 复旦大学附属华山医院中西医结合科
出处 《医学综述》 2011年第4期530-533,共4页 Medical Recapitulate
关键词 肿瘤 血管内皮生长因子 表达 调控 Cancer Vascular endothelial growth factor Expression Regulation
分类号 R730.2 [医药卫生—肿瘤]
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参考文献30

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同被引文献28

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医学综述
2011年 第4期

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