摘要
RACK1(蛋白激酶C受体)是一种色氨酸-天门冬氨酸域(WD40结构)重复蛋白。它是一种多功能支架蛋白,结合来自不同转导通路的信号分子并在多种哺乳动物发育过程中起关键作用。在植物中也存在RACK1同源基因,如拟南芥基因组有3个编码RACK1蛋白质的基因,这3个蛋白质与哺乳动物RACK1在氨基酸水平的相似性都超过75%。此外,植物RACK1蛋白质包含的WD40数量、位置和蛋白激酶C结合位点的结构域在很大程度上是保守的。该文对植物RACK1蛋白的发现、结构及其在信号转导方面的功能进行综述。
The receptor for activated C kinase 1 （RACK1） is a tryptophan-aspartic acid-domain （WD40） repeat protein. Compelling evidence supports that RACK1 is a versatile scaffold protein that binds numerous signaling molecules from diverse signal transduction pathways and plays critical roles in multiple developmental processes in mammals. RACK1 orthologs are also present in plants. In particular, the Arabidopsis genome contains genes that encode 3 RACK1 proteins, all of which show greater than 75% amino acid similarity to mammalian RACK1. In addition, all functional domains of RACK1 protein, including the number and position of WD40 repeats and the protein kinase C binding sites, are largely conserved in plant RACK1 proteins. We review the discovery, structure and signal transduction functions of plant RACK1.
出处
《植物学报》
CAS
CSCD
北大核心
2011年第2期224-232,共9页
Chinese Bulletin of Botany
基金
863计划(No.2008AA10Z120)
江苏省博士后基金(No.0901018B)
河南省教育厅自然科学基金(No.2010C18002)
关键词
ABA
G蛋白
RACK1
信号转导
abscisic acid, G protein, receptor for activated C kinase 1, signal transduction
