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mdr1及P-gP与脑胶质瘤耐药关系的研究 被引量：1

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摘要 恶性胶质瘤患者平均生存期较短,通常手术切除肿瘤组织并不能从根本上延长患者的生存时间,而且应用药物化疗易产生多药耐药性（multidrug resistance,MDR）,使化疗失败。P-糖蛋白（P-glycoprotein,P-gp）和多药耐药相关蛋白（multidrug resistance associated protein,MRP）介导的药物外排是产生MDR的主要机制,其编码基因分别为mdr1和 mrp1。
作者 付旭东 张艳艳 王新军 寿记新 宋来君
机构地区 郑州大学第五附属医院神经外科 郑州大学第一附属医院神经外科 郑州大学基础医学院
出处 《天津医药》 CAS 北大核心 2011年第2期169-170,共2页 Tianjin Medical Journal
关键词 脑肿瘤 神经胶质瘤 细胞系 肿瘤 P糖蛋白 多药耐药相关蛋白质类 流式细胞术 逆转录 聚合酶链反应
分类号 R730.53 [医药卫生—肿瘤]
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共引文献17

同被引文献16

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天津医药
2011年 第2期

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