摘要
目的观察氯吡格雷联用阿司匹林的抗血小板治疗不稳定型心绞痛的临床疗效及安全性。方法选取不稳定型心绞痛患者76例,随机分为两组,对照组38例,接受阿司匹林及低分子肝素治疗,阿司匹林每日100mg(首剂300mg),低分子肝素皮下注射7d,同时给予硝酸酯类、β-受体阻滞剂、ACE-I及他汀类等药物,治疗组38例,在对照组基础上加用氯吡格雷口服,每日75mg,随访1个月,行12导联24h动态心电图检查,计算24h内缺血型ST段的次数、持续时间及心肌缺血总负荷,观察两组患者每天心绞痛发作的频率及持续时间、硝酸甘油日用量、血小板和白细胞计数及皮肤粘膜的出血情况。结果治疗组硝酸甘油使用量及心绞痛发作次数明显<对照组(P<0.01)2,4h动态心电图比较两组心肌缺血改善情况治疗组也明显优于对照组(P<0.05),治疗组总有效率94.73%明显优于对照组81.58%(P<0.01),且无严重出血并发症。结论氯吡格雷联用阿司匹林的抗血小板治疗不稳定型心绞痛效果满意,安全性高。
Objective Observation of clopidogrel combined with aspirin anti-polatelet theraev in unstable angina clinical efficacv and safetv.Methods Selected patients with unstable angina pectoris 76 cases were randomly divided into two groups.38 cases of the control group to receive aspirin and low molecular weight heparin treatment.daily aspirin 100mg（first dose 300mg）.low-molecular-weight liver Su-subcutaneous in jection of 7 days.At the same time give nitrates.β-receptor blockers.ACE-I and drugs such as statins.The treatment group 38 cases.in the control group based on the oral use of Clopidogrel.75mg daily follow-up in January.the 12-lead ECG 24h dynamic calculated within 24h of ischemic ST-freqency.duration and the total load of mvocardial iscbemia.patients were observed daily the frequency of angina pectoris and duration.the amount of nitroglvcerin on platelet and white blood cell count and mucocutaneous bleeding situation.Results Nitroglvcerin treatment group and the use of significantly less than the number of angina pectoris group（P0.01）.24h Holter monitoring of mvocardial ischemia were compared between two groups to improve the situation of the treatment group was significantly better than the control group（P0.05）.The total effective rate in treatment group was superior to 94.73%in control group 81.58%（P0.01）.and no severe bleeding complications.Conclusion Clopidogrel combined with aspirin′s anti-platelet effect of treatment of unstable angina pectoris satisfied with satety.
出处
《四川医学》
CAS
2011年第3期385-387,共3页
Sichuan Medical Journal
