摘要
目的探讨原发性高血压(EH)患者颈动脉粥样硬化(CAS)与C-肽、唾液酸的关系。方法收集50例EH伴CAS患者和43例EH不伴CAS患者的人体学指标、既往史、实验室检测和骨密度检查数据,进行统计学分析。结果 EH伴CAS组与EH不伴CAS组比较,C-肽、唾液酸、胰岛素、C反应蛋白、血尿酸、年龄、舒张压、脉压差、吸烟、冠心病和骨质疏松发生率等因素差异有统计学意义(P<0.05),多因素分析显示,年龄、吸烟(少量)、唾液酸和C-肽是CAS的独立危险因素。结论 EH患者C-肽、唾液酸等指标与CAS关系密切,并参与了CAS的发生发展。
Objective To investigate the relation between carotid atherosclerosis（CAS） in essential hypertension（EH） patients and C-peptide and sialic acid.Methods The main anthropometry index,past medical history,the data of laboratory detection and bone mineral density from 50 EH cases with CAS and 43 EH cases without CAS were collected and analyzed statistically.Results There were significant difference in C-peptide,SA,INS,CRP,UA,age,DBP,PP,smoking,coronary heart disease and the prevalence of osteoporosis between the group of 50 EH cases with CAS and 43 EH without CAS cases（P〈0.05）.The age,smoking,SA and C-peptide were the independent risk factors after multivariate analysis.Conclusion There is a close relationship between carotid atherosclerosis of hypertensive patients and serum C-peptide,sialic acid.These factors are involved in the development of CAS.
出处
《东南国防医药》
2011年第1期34-36,共3页
Military Medical Journal of Southeast China
