摘要
目的了解深圳市宝安区孕产妇及新生儿梅毒患病情况,为制定预防与控制梅毒发病和流行的策略提供依据。方法对236853例首次产前保健的孕产妇进行免费甲苯胺红不加热血清试验(TRUST)筛查,试验结果呈阳性者采用梅毒螺旋体明胶颗粒凝聚试验(TPPA)进行确认;其分娩的新生儿1个月内用TRUST,TPPA及19S-IgM-梅毒螺旋体明胶凝集试验(19S-IgM-TPPA)进行检测;对孕妇及新生儿确诊试验结果呈阳性者进行规范治疗,电话随访并进行健康教育。结果 818例孕产妇确诊为妊娠梅毒,患病率为3.45‰;孕妇首次筛查时间多数在孕28周以前;潜伏期梅毒占多数;死胎、死产和自然流产112例,75例终止妊娠;失访117例;多数孕产妇及新生儿TRUST的滴度≤1∶4,12例新生儿血清19S-IgM-TPPA检测阳性;分娩的415例新生儿主要是先天梅毒疑似病例,12例为先天梅毒,阳性率为2.89%。结论早期梅毒筛查、规范治疗、定期随访和科学管理妊娠梅毒是控制梅毒母婴传播的有效方法 。
Objective To survey status of pregnant women and neonates who infected syphilis in Baoan District of Shenzhen. and to provide the scientific proof for syphilis prevention and treatment strategies making. Methods A total of 236 853 initial antenatal care pregnant women were given a blood screen for syphilis by Toluidine Red Unheated Serum Test（TRUST） free, and the positive cases were confirmed by Treponema Pallidum Particle Assay（TPPA）; Their neonates were detected by the same test and 19S-IgM-TPPA within postnatal one month; all the positive cases were dealed with standard treatment, and were given health education regularly through telephone. Results Eight hundred and eighteen cases were diagnosis as syphilis finally, the prevalence rate of pregnancy syphilis was 3.45%v; most women were examined before 28 gestational weeks ; and primarily were latent syphilis; The occurrences of fetal intrauterine death, stillbirth and natural abortion were 112, and 75 chosed termination of pregnancy; 117 cases were missed because of patients or their family uncooperative; serum test indicated that most pregnant women and neonates TRUST titre ≤ 1：4, 12 cases of neonates serology 19S-IgM-TPPA were positive;415 neonates mainly were suspected congenital syphilis, 12 cases were congenital syphilis（CS） with positive rate of 2.89%. Conclusion It is an effection method to control syphilis maternal-neonatal transmission by syphilis screening early, standard treatment, regular follow up,scientific management of pregnancy syphilis.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2011年第3期212-214,244,共4页
The Chinese Journal of Dermatovenereology
关键词
孕产妇
新生儿
梅毒
Pregnant woman
Neonate
Syphilis
