摘要
目的观察中药补肾活血饮配合西药治疗帕金森病(PD)的临床疗效。方法采用随机对照试验,纳入PD患者100例,剔除5例、脱落4例,完成研究者共91例。其中治疗组(中药+西药组)47例,对照组(西药组)44例,疗程3个月。采用统一帕金森病评定量表(UPDRS)评分、H-Y分级的变化来评价治疗的有效率、运动功能的改善情况等。结果治疗组有效率44.68%,疗效优于对照组(11.36%,P<0.05)。治疗组治疗后各时间点UPDRS总分较对照组下降明显(P<0.05)。治疗组各时间点UPDRSⅡ评分与治疗前相比明显降低(P<0.01),对照组仅治疗后1个月较治疗前降低(P<0.05);与对照组比较,治疗后2、3个月时治疗组UP-DRSⅡ评分下降更为明显(P<0.05)。治疗组各时点UPDRSⅢ评分与治疗前相比明显降低(P<0.01),对照组在治疗后1、3个月较治疗前降低(P<0.05)。两组间UPDRSⅢ评分、H-Y分级变化差异无统计学意义(P>0.05)。结论补肾活血饮具有增效减毒作用,与西药联合应用在改善PD患者的运动功能和日常生活能力方面优于单用西药。
Objective To investigate the clinical effect of ＂BUSHEN HUOXUE YIN＂（BHY,a Chinese traditional medicine） combined with western medicine on patients with Parkinson’s disease（PD）.Methods One hundred PD patients were enrolled in the randomized control trial（RCT）.The patients were randomly divided into two groups（50 each）： treatment group（BHY and western medicine,peros） and control group（western medicine only,peros）.At the end of the 3rd month,47 patients in treated group and 44 patients in control group completed the trials,as 5 patients were excluded and 4 patients lost follow-up.The Unified Parkinson’s Disease Rating Scale（UPDRS） scoring and the Hoehn ＆ Yahr stage（H-Y） were compared before and after treatment to evaluate the improvement of motor function and clinical efficacy.Results The effective power was significantly higher in treatment group（44.68%） than in control group（11.36%,P〈0.05）.The total UPDRS score decreased significantly in treatment group than in control group at any time point after treatment（P〈0.05）.In treatment group,post-treatment UPDRS Ⅱ score decreased significantly at each time point compared with that of prior treatment;in control group,UPDRS Ⅱ score showed significant difference only after one-month of treatment compared with that before treatment（P〈0.05）.Compared with control group,UPDRS Ⅱ score in treatment group decreased significantly two and three months after treatment（P〈0.05）.In treatment group,post-treatment UPDRS III score at each time point decreased significantly compared with that prior to treatment,while in control group,UPDRS III score showed significant difference one month and three months after treatment compared with that before treatment（P〈0.05）.No significant difference was found in UPDRS III score or H-Y between the two groups（P〉0.05）.Conclusion BHY has an obvious therapeutic effect on PD patients.BHY combined with western medicine can improve motor function and daily living activity in PD patients better than western medicine only.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2011年第3期273-276,共4页
Medical Journal of Chinese People's Liberation Army
基金
"十一五"国家科技支撑计划重大项目资助课题(2006BAI04A11-1)
关键词
帕金森病
补肾活血饮
中西医结合疗法
治疗
临床研究性
Parkinson＇s disease
BUSHEN HUOXUE YIN
therapy, integration of Chinese and Western medicine
therapy, investigational
