摘要
目的 探讨雌激素受体（ Ｅ Ｒ）与原发胆囊癌临床病理间的关系。方法 应用免疫组化技术对３６ 例原发胆囊癌组织中的雌激素受体进行了检测。结果 ３６ 例原发胆囊癌组织中（ Ｅ Ｒ）阳性表达率为６３．９％ （２３／３６）， Ｅ Ｒ阳性的胆囊癌 Ｐ Ｃ Ｎ Ａ 指数显著高于阴性者（ Ｐ＜ ０．０１）； Ｅ Ｒ阳性与原发胆囊癌的分化程度、侵袭转移密切相关（ Ｐ＜ ０．０５）； Ｅ Ｒ阳性者胆囊患者的累计生存率低于 Ｅ Ｒ阴性者。结论 Ｅ Ｒ阳性的原发胆囊癌有较差的生物学行为和预后。
Objective To investigate the clinicopathologic significance of estrogen recepter(ER) in galladder carcinoma.Methods ER and PCNA were detected in 36 cases of gallbladder cacinomas with immunohistochemical stain.Result Expression rate of ER in tumor tissue was found in 63.9%(23/36) of patients,The PCNA labled index in ER positive gallbladder carcinoma was significanly lower than that in ER negtive gallbladder carcinoma,(P<0.01);ER positively correlated with differentiation,invassion,metastasis and nevin stage (P<0.05),ER positive group showed significantly decreased surrival rae than that in ER gentive group (P<0.05).Conclusion ER negtive gallbladder carcinoma had less malignant biogial behavior and better prgnosis thannegtive gallbladder carcinoma.
出处
《肝胆外科杂志》
1999年第4期312-313,共2页
Journal of Hepatobiliary Surgery
